EXPRESSION OF CONCERN: Mechanisms of Synthetic Serine Protease Inhibitor (FUT-175)-Mediated Cell Death

Abstract

EXPRESSION OF CONCERN: T. Uwagawa, Z. Li, Z. Chang, Q. Xia, B. Peng, G. M. Sclabas, S. Ishiyama, M.-C. Hung, D. B. Evans, J. L. Abbruzzese, and P. J. Chiao, “Mechanisms of Synthetic Serine Protease Inhibitor (FUT-175)-Mediated Cell Death,” Cancer 109, no. 10 (2007): 2142-2153, https://doi.org/10.1002/cncr.22658.

This Expression of Concern is for the above article, published online on 04 April 2007 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Suresh S. Ramalingam; the American Cancer Society; and Wiley Periodicals LLC. The Expression of Concern has been published due to concerns raised by a third party regarding inconsistencies identified between Figure 1D and Figure 2D. The figures depict bands from the same experimental conditions and while the band of IκBα lane – 80 µg/ml FUT175 is identical in both figures, the corresponding β-actin loading control band is different.

The authors were informed about the concerns, but due to the time elapsed since publication, the raw data was not available. Without an explanation of the anomaly in the figure and in the absence of the original raw data, the journal team could not verify the authenticity of this figure. Although the inconsistencies found in the figures likely do not affect the results and the conclusions of this publication, the journal has decided to issue an Expression of Concern to inform the readers.