Fast ripple band high-frequency activity associated with thalamic sleep spindles in pediatric epilepsy.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-01-30 DOI:10.1016/j.clinph.2025.01.011

Atsuro Daida, Yuanyi Ding, Yipeng Zhang, Shingo Oana, Saarang Panchavati, Benjamin D Edmonds, Samuel S Ahn, Noriko Salamon, Raman Sankar, Aria Fallah, Richard J Staba, Jerome Engel, William Speier, Vwani Roychowdhury, Hiroki Nariai

{"title":"Fast ripple band high-frequency activity associated with thalamic sleep spindles in pediatric epilepsy.","authors":"Atsuro Daida, Yuanyi Ding, Yipeng Zhang, Shingo Oana, Saarang Panchavati, Benjamin D Edmonds, Samuel S Ahn, Noriko Salamon, Raman Sankar, Aria Fallah, Richard J Staba, Jerome Engel, William Speier, Vwani Roychowdhury, Hiroki Nariai","doi":"10.1016/j.clinph.2025.01.011","DOIUrl":null,"url":null,"abstract":"Objective: To investigate high-frequency activities (HFA) associated with thalamic sleep spindles.Methods: We studied a cohort of ten pediatric patients with medication resistant epilepsy who were identified as potential candidates for thalamic neuromodulation. These patients had thalamic sampling as well as presumed epileptogenic zones, using stereotactic EEG (SEEG) with a sampling frequency of 2,000 Hz. We quantified the summated high-frequency activity (HFA) in the fast ripple band associated with sleep spindles using 20-minute scalp EEG and SEEG recordings during non-REM sleep and analyzed its correlation with spindle characteristics.Results: HFA, with a median peak frequency of 330 Hz, was distinctively observed in the thalamus and temporally correlated with thalamic sleep spindles. Such HFA demonstrated significant coupling with the sleep spindle range of 11-16 Hz. The duration of HFA positively correlated with higher density and longer duration of accompanying thalamic spindles. Thalamic HFA's duration negatively correlated with the presence of cortical interictal epileptiform discharges. Thalamic spindles generated in channels with HFA often coincided with sleep spindles in various brain regions.Conclusion: Fast ripple band HFA associated with sleep spindles was observed exclusively in the thalamus.Significance: Thalamic HFA associated with thalamic spindles may represent a thalamus-specific physiological phenomenon.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.clinph.2025.01.011","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To investigate high-frequency activities (HFA) associated with thalamic sleep spindles.

Methods: We studied a cohort of ten pediatric patients with medication resistant epilepsy who were identified as potential candidates for thalamic neuromodulation. These patients had thalamic sampling as well as presumed epileptogenic zones, using stereotactic EEG (SEEG) with a sampling frequency of 2,000 Hz. We quantified the summated high-frequency activity (HFA) in the fast ripple band associated with sleep spindles using 20-minute scalp EEG and SEEG recordings during non-REM sleep and analyzed its correlation with spindle characteristics.

Results: HFA, with a median peak frequency of 330 Hz, was distinctively observed in the thalamus and temporally correlated with thalamic sleep spindles. Such HFA demonstrated significant coupling with the sleep spindle range of 11-16 Hz. The duration of HFA positively correlated with higher density and longer duration of accompanying thalamic spindles. Thalamic HFA's duration negatively correlated with the presence of cortical interictal epileptiform discharges. Thalamic spindles generated in channels with HFA often coincided with sleep spindles in various brain regions.

Conclusion: Fast ripple band HFA associated with sleep spindles was observed exclusively in the thalamus.

Significance: Thalamic HFA associated with thalamic spindles may represent a thalamus-specific physiological phenomenon.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.