{"title":"Opposing and segregated cortical circuits control winning and losing behaviors.","authors":"Elizabeth Illescas-Huerta, Nancy Padilla-Coreano","doi":"10.1016/j.neuron.2025.01.007","DOIUrl":null,"url":null,"abstract":"<p><p>In this issue of Neuron, Xin et al.<sup>1</sup> reveal how the dorsomedial prefrontal cortex (dmPFC) orchestrates social dominance through subcortical pathways to the amygdala and brainstem. Using optogenetics and functional mapping, they identify opposing win- and lose-related circuits, uncovering a laminar organization driving competitive behavior in mice.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"113 3","pages":"335-336"},"PeriodicalIF":15.0000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuron.2025.01.007","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
In this issue of Neuron, Xin et al.1 reveal how the dorsomedial prefrontal cortex (dmPFC) orchestrates social dominance through subcortical pathways to the amygdala and brainstem. Using optogenetics and functional mapping, they identify opposing win- and lose-related circuits, uncovering a laminar organization driving competitive behavior in mice.
期刊介绍：
Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.
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