Xuehao Hu, Xiu Yang, Liangqun Li, Lijuan Ge, Qiji Li, Xiaosheng Yang, Juan Yang, Ming Gao
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引用次数: 0
Abstract
Three new polyketides, actinofuranones J (1) and K (2), nocapyrone S (3), with one known compound nocapyrone Q (4) were isolated from the culture broth of a Karst cave-derived Streptomyces sp. (FD-2-6). Their structures were elucidated by comprehensive analysis of NMR spectroscopic data, HR-MS and electronic circular dichroism (ECD) data. The antitumour and antibacterial activities of 1-4 were investigated by examining their IC50 and MIC values in MCF-7 human breast cancer cells, human hepatocellular carcinoma HepG2 cells and human cervical cancer Hela cells, and Klebsiella pneumoniae sp, Pseudomonas aeruginosa sp, Mycolicibacterium smegmatis sp, Escherichia coli sp, Staphylococcus aureus sp. Compounds 1-4 showed weak inhibitory effect on antitumour activity on MCF-7 human breast cancer cells, and human cervical cancer Hela cells.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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