Adenovirus Infections and Disease in Solid Organ Transplant Recipients: Incidence and Outcomes.

IF 3.8 4区医学 Q2 IMMUNOLOGY Open Forum Infectious Diseases Pub Date : 2025-01-20 eCollection Date: 2025-02-01 DOI:10.1093/ofid/ofaf032

Katrine Riishøj Grarup, Søren Schwartz Sørensen, Michael Perch, Nicolai Schultz, Finn Gustafsson, Vibeke Brix Christensen, Kristian Schønning, Kasper Sommerlund Moestrup, Jens Lundgren, Cornelia Geisler Crone, Marie Helleberg

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Abstract

Background: We aimed to examine the epidemiology and outcomes of AdV disease in SOTr and assess the utility of AdV surveillance in SOTr <13 years.

Methods: SOTr transplanted at Rigshospitalet, 2010-2021, were included. The center had a screening program for SOTr <13 years with monthly plasma AdV tests the first 6 months following transplantation.

Results: We included 2009 SOTr (of whom 82 were aged <13 years), and 1330 blood samples from 382 SOTr were analyzed for AdV, of which 10 (0.8%) from 6 SOTr <13 years tested positive. Five out of six were tested as part of the screening program. Three remained asymptomatic, while three had symptoms attributable to co-infections. One adult lung transplant recipient with AdV in BAL had acute exacerbation of chronic graft rejection.

Conclusions: We found a low incidence of AdV disease. SOTr diagnosed with AdV viremia as part of screening remained asymptomatic or had symptoms attributable to co-infections. Our findings do not support routine surveillance for AdV in SOTr.

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.