Durga Kulkarni, Bohee Lee, Nabihah Farhana Ismail, Ahmed Ehsanur Rahman, Julia Spinardi, Moe H Kyaw, Harish Nair
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引用次数: 0
Abstract
Background: Our previous systematic review estimated the cumulative incidence of SARS-CoV-2 reinfections as 1.16% (95% CI = 1.01-1.33%) during the pre-Omicron period. The Omicron variant that emerged in November 2021 was significantly genetically distinct from the previous SARS-CoV-2 variants and thus, more transmissible and posed an increased risk of SARS-CoV-2 reinfections in the population. We, therefore, conducted a fresh systematic review and meta-analysis to estimate the SARS-CoV-2 reinfection burden during the Omicron period.
Methods: We searched CINAHL, Medline, Global Health, Embase, and WHO COVID-19 in October 2023 for studies reporting the SARS-CoV-2 reinfection incidence during the Omicron period. The quality of the included studies was assessed using the Joanna Briggs Institute checklists. Random effects meta-analyses were conducted to estimate the incidence, and requirement of hospitalisation of SARS-CoV-2 reinfections. Symptomatic severity of reinfections and case fatality rates were analysed narratively.
Results: Thirty-six studies were included. The reinfection cumulative incidence during the Omicron period was 3.35% (95% CI = 1.95-5.72%) based on data from 28 studies. The cumulative incidence was higher in 18-59-year-old adults (6.62% (95% CI = 3.22-13.12%)) compared to other age groups and in health care workers (9.88% (95% CI = 5.18-18.03%)) compared to the general population (2.48% (95% CI = 1.34-4.54%)). We estimated about 1.81% (95% CI = 0.18-15.87%) of the reinfected cases required hospitalisation based on limited and highly variable data.
Conclusions: There was an increased risk of reinfections during the Omicron period compared to the pre-Omicron period. The incidence was higher in 18-59-year-old adults and health care workers and generally less severe during the Omicron period. However, data were limited on disease severity and long-term outcomes.
背景：我们之前的系统评价估计，在前欧米克隆时期，SARS-CoV-2再感染的累积发生率为1.16% （95% CI = 1.01-1.33%）。2021年11月出现的欧米克隆变体在遗传上与以前的SARS-CoV-2变体明显不同，因此更具传染性，并增加了人群中SARS-CoV-2再感染的风险。因此，我们进行了一项新的系统评价和荟萃分析，以估计欧米克隆期间SARS-CoV-2再感染负担。方法：我们于2023年10月检索了CINAHL、Medline、Global Health、Embase和WHO COVID-19，检索了报道了Omicron期间SARS-CoV-2再感染发生率的研究。采用乔安娜布里格斯研究所的检查表对纳入研究的质量进行评估。采用随机效应荟萃分析估计SARS-CoV-2再感染的发生率和住院需求。对再感染的症状严重程度和病死率进行叙述分析。结果：纳入36项研究。根据28项研究的数据，Omicron期间的再感染累积发生率为3.35% （95% CI = 1.95-5.72%）。与其他年龄组相比，18-59岁的成年人（6.62% (95% CI = 3.22-13.12%)）的累积发病率较高，卫生保健工作者（9.88% (95% CI = 5.18-18.03%)）的累积发病率高于一般人群（2.48% (95% CI = 1.34-4.54%)）。根据有限和高度可变的数据，我们估计约1.81% （95% CI = 0.18-15.87%）的再感染病例需要住院治疗。结论：与前欧米克隆时期相比，欧米克隆期间再次感染的风险增加。18-59岁的成年人和卫生保健工作者的发病率较高，在欧米克隆期间通常不那么严重。然而，关于疾病严重程度和长期结果的数据有限。注册：普洛斯彼罗：CRD42023482598。
期刊介绍：
Journal of Global Health is a peer-reviewed journal published by the Edinburgh University Global Health Society, a not-for-profit organization registered in the UK. We publish editorials, news, viewpoints, original research and review articles in two issues per year.
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