Enhanced Photothermal Tumor Ablation Using Polypyrrole-Gold Nanocomposites Activated by Polarized Polychromatic Low-Energy Light: An In Vivo Study.

Abstract

Photothermal therapy (PTT) offers a minimally invasive approach for cancer treatment, using light energy to selectively heat and destroy cancer cells. Success in PTT depends on efficient, stable, and biocompatible photothermal agents. This study investigates polypyrrole@gold nanocomposites (PPy@Au NCs) as photothermal agents combined with polarized polychromatic low-energy light (PPLEL) to target tumors and limit disease progression. In vivo experiments on Ehrlich carcinoma-bearing female Swiss albino mice demonstrated that PPy@Au NCs selectively accumulated in tumor tissue and, when activated by PPLEL, generated sufficient heat for effective tumor ablation. This approach enhanced treatment efficacy and presented a cost-effective solution due to the affordability of both the nanocomposite and light source. Histopathological analysis confirmed significant tumor reduction, suggesting that this synergistic combination offers a promising cancer treatment strategy. Findings support further research and potential clinical applications in photothermal cancer therapy.