{"title":"Oncofetal reprogramming induces phenotypic heterogeneity in colorectal cancer","authors":"","doi":"10.1038/s41588-025-02092-7","DOIUrl":null,"url":null,"abstract":"Phenotypic plasticity of cancer cells is increasingly recognized as a mechanism of tumor escape from targeted therapies. Yet, the phenotypic heterogeneity of colorectal cancer remains poorly explored. Our study identifies oncofetal reprogramming of neoplastic stem cells, driven by the transcription factors YAP and AP-1, as a critical driver of phenotypic heterogeneity, lineage plasticity and therapy resistance. Targeting the oncofetal program enhances the efficacy and durability of current treatments.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"57 2","pages":"285-286"},"PeriodicalIF":29.0000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature genetics","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41588-025-02092-7","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Phenotypic plasticity of cancer cells is increasingly recognized as a mechanism of tumor escape from targeted therapies. Yet, the phenotypic heterogeneity of colorectal cancer remains poorly explored. Our study identifies oncofetal reprogramming of neoplastic stem cells, driven by the transcription factors YAP and AP-1, as a critical driver of phenotypic heterogeneity, lineage plasticity and therapy resistance. Targeting the oncofetal program enhances the efficacy and durability of current treatments.
期刊介绍：
Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation.
Integrative genetic topics comprise, but are not limited to:
-Genes in the pathology of human disease
-Molecular analysis of simple and complex genetic traits
-Cancer genetics
-Agricultural genomics
-Developmental genetics
-Regulatory variation in gene expression
-Strategies and technologies for extracting function from genomic data
-Pharmacological genomics
-Genome evolution
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
