Innovative approaches to asthma treatment: harnessing nanoparticle technology

IF 4.1 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Nanoscale Research Letters Pub Date : 2025-02-08 DOI:10.1186/s11671-025-04211-z
Vanshika Goswami, Kushneet Kaur Sodhi, Chandra Kant Singh
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Abstract

In the domain of respiratory illnesses, asthma remains a critical obstacle. The heterogeneous nature of this chronic inflammatory disease poses challenges during its treatment. Glucocorticoid-based combination drug therapy now dominates clinical treatments for asthma; however, glucocorticoid resistance, numerous adverse effects, the incidence of inadequate drug delivery, and other factors need the development of more effective therapies. In recent years, there has been extensive research on nanotechnology in medicine. It has been shown in studies that these drug delivery systems can greatly enhance targeting and bioavailability and decrease the toxicity of medication. Nanoparticle drug delivery systems offer improved therapeutic efficacy compared to conventional administration techniques. Nanotechnology enables advancements in precision medicine, offering benefits for heterogeneous conditions such as asthma. This review will examine the critical factors of asthma to consider when formulating medications, as well as the role of nanomaterials and their mechanisms of action in pulmonary medicine for asthma treatment.

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哮喘治疗的创新方法:利用纳米颗粒技术
在呼吸系统疾病领域,哮喘仍然是一个严重的障碍。这种慢性炎症性疾病的异质性在治疗过程中提出了挑战。以糖皮质激素为基础的联合药物治疗目前在哮喘的临床治疗中占主导地位;然而,糖皮质激素耐药、众多不良反应、药物递送不足的发生率以及其他因素需要开发更有效的治疗方法。近年来,纳米技术在医学上得到了广泛的研究。研究表明,这些给药系统可以大大提高药物的靶向性和生物利用度,降低药物的毒性。与传统给药技术相比,纳米颗粒给药系统提供了更好的治疗效果。纳米技术促进了精准医疗的进步,为哮喘等异质性疾病提供了益处。本综述将探讨在制定药物时需要考虑的哮喘的关键因素,以及纳米材料在肺部药物治疗哮喘中的作用及其作用机制。
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来源期刊
Nanoscale Research Letters
Nanoscale Research Letters 工程技术-材料科学:综合
CiteScore
11.30
自引率
0.00%
发文量
110
审稿时长
48 days
期刊介绍: Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.
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