Qi Lin MSc , Huan Chen MSc , Shuyao Zheng MSc , Lingkang Lin MSc , Song Zhu PhD
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引用次数: 0
Abstract
Statement of problem
Research on antibacterial dental adhesives has increased over the last few years. However, whether antibacterial agents improve the efficacy of dentin bonding has not yet been determined.
Purpose
The purpose of this systematic review and meta-analysis was to evaluate whether antibacterial agents improve the efficacy of dentin bonding at the resin-dentin interface and to identify possible mechanisms.
Material and methods
Studies published within the last 10 years up to April 2024 were searched in 5 databases: PubMed (MedLine), EMBASE, Scopus, Web of Science, and Cochrane Library. A random-effects meta-analysis model was used, and pooled effect estimates were obtained by comparing the standardized mean difference (α=.05).
Results
A total of 61 studies with 9 different types of antibacterial agent were included in the qualitative and quantitative analyses. The meta-analysis indicated that treatment with metal-based inorganic antibacterial agents improved both the immediate and long-term bond strength values (P<.05). Moreover, incorporating carbon-based substances, quaternary ammonium compounds, chlorhexidine, methacrylate derivatives, and antibiotics enhanced the long-term bond strength of the resin composites to dentin (P<.05). Subgroup analysis indicated that including metal-based inorganic antibacterial agents, quaternary ammonium compounds, and methacrylate derivatives in etch-and-rinse (ER) adhesives improved dentin bond strength (P<.05), whereas carbon-based materials in self-etching (SE) adhesives showed better bonding performance.
Conclusions
The introduction of some antibacterial agents into the bonding system improved in vitro bond strength and inhibited bacterial growth. However, clinical trials should be conducted to verify in vivo antibacterial effects and bond strength.
期刊介绍：
The Journal of Prosthetic Dentistry is the leading professional journal devoted exclusively to prosthetic and restorative dentistry. The Journal is the official publication for 24 leading U.S. international prosthodontic organizations. The monthly publication features timely, original peer-reviewed articles on the newest techniques, dental materials, and research findings. The Journal serves prosthodontists and dentists in advanced practice, and features color photos that illustrate many step-by-step procedures. The Journal of Prosthetic Dentistry is included in Index Medicus and CINAHL.
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