Sheer drop ahead: reviewing sarcopenia outcomes in elderly patients undergoing bariatric surgery.

IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-10-01 Epub Date: 2025-02-08 DOI:10.1007/s11154-025-09946-9
Matheo Augusto Morandi Stumpf, Cintia Cercato, Maria E de Melo, Marcio C Mancini
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Abstract

The global prevalence of obesity among elderly patients continues to rise. Despite the availability of new antiobesity medications, bariatric surgery remains an effective treatment option for carefully selected candidates. However, it is not risk-free, especially in a vulnerable population, predisposing to falls, fractures and sarcopenia. Following bariatric surgery, there is rapid loss of muscle mass, particularly within the first 3 months. Muscle quality, on the other hand, characterized by functionality and indirectly assessed through strength tests, appears to be preserved. This is attributed to reductions in ectopic intramuscular fat deposits. Strategies to mitigate muscle loss and functional impairment include combined exercises (resistive and aerobic training), adequate protein and vitamin D intake, beta-hydroxy-beta-methylbutyrate (HMB) supplementation, and testosterone replacement therapy for men with confirmed hypogonadism. It is important to emphasize that, to date, no specific trial has evaluated the current sarcopenia criteria in elderly patients undergoing bariatric surgery. Therefore, future studies are needed to assess this particularly vulnerable population, not only to monitor changes in muscular health, but also to develop strategies for preventing therapeutic inertia.

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完全下降:回顾接受减肥手术的老年患者肌肉减少症的结果。
全球老年肥胖症患病率持续上升。尽管有新的抗肥胖药物,但对于精心挑选的候选人来说,减肥手术仍然是一种有效的治疗选择。然而,它不是没有风险的,特别是在脆弱人群中,容易跌倒,骨折和肌肉减少症。在减肥手术后,肌肉量会迅速减少,尤其是在头3个月内。另一方面,以功能为特征并通过力量测试间接评估的肌肉质量似乎得到了保留。这归因于异位肌内脂肪沉积的减少。减轻肌肉损失和功能损害的策略包括联合运动(阻力和有氧训练),摄入足够的蛋白质和维生素D,补充β -羟基- β -甲基丁酸盐(HMB),以及对确诊性腺功能减退的男性进行睾酮替代治疗。需要强调的是,到目前为止,还没有专门的试验评估接受减肥手术的老年患者目前的肌肉减少症标准。因此,未来的研究需要评估这一特别脆弱的人群,不仅要监测肌肉健康的变化,还要制定预防治疗惰性的策略。
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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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