{"title":"Regulation roles of dre-miR-187 in neurological damage by low concentration toluene in zebrafish","authors":"Shu-Hui Men, Jia-Yun Xu, Zhen-Guang Yan, Jin-Zhe Du, Ming-Rui Li, Zi-Ye Wang, Chen Liu, Xin Zheng","doi":"10.1016/j.jclepro.2025.144973","DOIUrl":null,"url":null,"abstract":"Toluene is a common organic pollutant in ambient water environment, and its potential toxicogenic mechanism remains unclear. In this study, we explored toxicity mechanisms of toluene on zebrafish and verified that toluene exposure at criterion concentration levels altered the blood-brain barrier (BBB) permeability, and 19 lncRNAs and 10 miRNAs associated with the BBB function showed significant differences. In addition, we confirmed that <em>dre-miR-187</em> binds complementarily to ABCC4 3'UTR, thereby inhibiting expression and affecting normal BBB function. By exploring the regulatory mechanism of ncRNA under toluene stress, we provided a new idea for studying neurotoxicity of toluene and its regulatory mechanism, and for the first time found that low concentration of toluene can disrupt BBB function in zebrafish.","PeriodicalId":349,"journal":{"name":"Journal of Cleaner Production","volume":"143 1","pages":""},"PeriodicalIF":9.7000,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cleaner Production","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1016/j.jclepro.2025.144973","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Toluene is a common organic pollutant in ambient water environment, and its potential toxicogenic mechanism remains unclear. In this study, we explored toxicity mechanisms of toluene on zebrafish and verified that toluene exposure at criterion concentration levels altered the blood-brain barrier (BBB) permeability, and 19 lncRNAs and 10 miRNAs associated with the BBB function showed significant differences. In addition, we confirmed that dre-miR-187 binds complementarily to ABCC4 3'UTR, thereby inhibiting expression and affecting normal BBB function. By exploring the regulatory mechanism of ncRNA under toluene stress, we provided a new idea for studying neurotoxicity of toluene and its regulatory mechanism, and for the first time found that low concentration of toluene can disrupt BBB function in zebrafish.
期刊介绍：
The Journal of Cleaner Production is an international, transdisciplinary journal that addresses and discusses theoretical and practical Cleaner Production, Environmental, and Sustainability issues. It aims to help societies become more sustainable by focusing on the concept of 'Cleaner Production', which aims at preventing waste production and increasing efficiencies in energy, water, resources, and human capital use. The journal serves as a platform for corporations, governments, education institutions, regions, and societies to engage in discussions and research related to Cleaner Production, environmental, and sustainability practices.
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