One-pot acid-catalysed synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and evaluation of cytotoxic activities†

IF 4.6 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY RSC Advances Pub Date : 2025-02-10 DOI:10.1039/D4RA08868A
Tran Quang Hung, Ban Van Phuc, Ha Nam Do, Thu Hue Tran, Hai Yen Nguyen, Nguyen Truong Phuoc, Truong Mai Chi, Dang Van Do, Truong T. T. Nga, Hien Nguyen, Van Tuyen Nguyen and Tuan Thanh Dang
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Abstract

A practical and efficient approach for the acid-catalysed synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethane (BimPy) derivatives has been described. Interestingly, these BimPys showed potential cytotoxicity against various cancer cell lines (SK-LU-1, MCF-7, HepG2).

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一锅酸催化合成双(1-咪唑[1,5-a]吡啶基)芳基甲烷及其细胞毒活性评价
介绍了一种酸催化合成双(1-咪唑[1,5- A]吡啶基)芳基甲烷(BimPy)衍生物的实用高效方法。有趣的是,这些BimPys显示出对多种癌细胞系(SK-LU-1, MCF-7, HepG2)的潜在细胞毒性。
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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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