Dental implants in solid organ transplant recipients: A systematic review and meta-analysis

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-02-06 DOI:10.1016/j.jormas.2025.102278

Yongying Chen , Liang Tang , Chufang Liao

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Abstract

Purpose

It remains to be determined whether dental implantation treatment in solid organ transplant (SOT) recipients and non-organ transplant patients yields similar clinical outcomes. This review summarizes related data for existing cases and presents a meta-analysis of the outcomes of dental implants in SOT recipients and non-organ transplant patients.

Material and methods

An electronic literature search was conducted in the PubMed, Web of Sciences, Cochrane Library and China National Knowledge Infrastructure databases covering articles published from inception to December 2024. This study was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was designed based on the Population, Intervention, Comparison, Outcome and Study design (PICOS) framework. The risk of bias was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist or the Newcastle-Ottawa Scale (NOS). The certainty of findings was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Meta-analysis was performed using a fixed effects model to estimate the combined performance measures and 95 % confidence intervals for the implant survival rate, marginal bone loss (MBL), and probing depth (PD).

Results

A total of 12 articles were included in the systematic review. The implant survival rate of 290 implants in 110 SOT recipients was 99.3 %. The meta-analysis of four case-control studies revealed no significant differences in the implant survival rate and PD between SOT recipients and non-organ transplant patients (P = 0.45 and P = 0.49, respectively), while there was slightly less MBL in SOT recipients (P = 0.02), possibly caused by confounding factors and bias.

Conclusions

Organ transplantation does not impair implant survival in the short and mid-long term. Dental implantation can serve as a treatment option for tooth loss in SOT recipients.

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实体器官移植受者的牙种植体：系统回顾和荟萃分析。

目的：牙种植治疗在实体器官移植（SOT）受者和非器官移植患者中是否产生相似的临床结果仍有待确定。本文综述了现有病例的相关数据，并对SOT受体和非器官移植患者种植牙的结果进行了荟萃分析。材料和方法：在PubMed， Web of Sciences， Cochrane Library和中国国家知识基础设施数据库中进行电子文献检索，涵盖从成立到2024年12月发表的文章。本研究按照PRISMA（系统评价和荟萃分析首选报告项目）指南进行，并基于人群、干预、比较、结果和研究设计（PICOS）框架进行设计。使用乔安娜布里格斯研究所（JBI）关键评估清单或纽卡斯尔-渥太华量表（NOS）评估偏倚风险。研究结果的确定性采用分级建议评估、发展和评价（GRADE）标准进行评估。采用固定效应模型进行meta分析，以估计种植体存活率、边缘骨质流失（MBL）和探探深度（PD）的综合性能指标和95%置信区间。结果：系统评价共纳入12篇文献。110例SOT受者290例种植体成活率为99.3%。4项病例对照研究的荟萃分析显示，SOT受者与非器官移植患者的种植体存活率和PD无显著差异（P=0.45和P=0.49），而SOT受者的MBL略少（P=0.02），可能是混杂因素和偏倚所致。结论：器官移植对移植体的短期和中长期存活均无影响。植牙可以作为SOT受者牙齿脱落的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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