DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies

Abstract

In an era of rapid scientific advancement, the need for engaging educational tools is critical. DEGRADATOR, a 2D computer game, bridges this gap by immersing players in the ubiquitin-proteasome system, a key pathway in cellular protein degradation. Designed for players aged 12 and above, DEGRADATOR introduces the molecular mechanics of targeted protein degradation, including PROTAC drugs. Through 10 levels of gameplay combined with educational quizzes, it represents the first-ever resource of its kind to make this advanced topic accessible and amusing. The game was evaluated by 97 high school students (age 15–19) during biology classes. Over 75% of students completed the game in under 30 min, and 63% rated it highly (4 or 5 out of 5) for its ability to enhance their understanding of protein degradation. In quizzes, 59% scored 10 or more points out of 12 on the final test, indicating substantial knowledge retention. Teachers highlighted the game’s potential for deepening students' comprehension and recommended accompanying materials to maximize educational impact. By blending entertainment with education, DEGRADATOR demystifies complex molecular processes, serving as a tool for popularizing science and addressing the potential misconceptions surrounding new therapeutic technologies. Freely available at https://degradator-game.com, DEGRADATOR is complemented by teacher resources and multimedia materials, ensuring broad applicability. This innovative platform not only supports classroom learning but also fosters curiosity and understanding beyond traditional academic settings.