Benzo[4,5]imidazole[2,1-b]quinazoline-1(2H)-one: An efficient fluorescent probe for the selective and sensitive detection of Cu(II) ions

Somi Santharam Roja , P. Sneha Sunil , Muhammad Maqsood Darussalam , Vidhyashree Manoharan , John Prakash , Raju Ranjith Kumar
{"title":"Benzo[4,5]imidazole[2,1-b]quinazoline-1(2H)-one: An efficient fluorescent probe for the selective and sensitive detection of Cu(II) ions","authors":"Somi Santharam Roja ,&nbsp;P. Sneha Sunil ,&nbsp;Muhammad Maqsood Darussalam ,&nbsp;Vidhyashree Manoharan ,&nbsp;John Prakash ,&nbsp;Raju Ranjith Kumar","doi":"10.1016/j.saa.2025.125853","DOIUrl":null,"url":null,"abstract":"<div><div>Copper (Cu) is essential for biological systems and animal-plant tissues, but Cu<sup>2+</sup> ions are also significant environmental pollutants. An imbalance in non-toxic Cu<sup>2+</sup> levels can lead to health issues. This study focuses on the development of a novel fluorescent turn-on probe, 3,4-dihydrobenzo[4,5]imidazole[2,1-<em>b</em>]quinazoline-1(2<em>H</em>)-one (<strong>HBQ</strong>) for the selective and sensitive detection of Cu<sup>2+</sup> ions. The synthesis of <strong>HBQ</strong> was achieved from the reaction of 2-((dimethylamino)methylene)-cyclohexane-1,3-dione and 2-aminobenzimidazole. The photophysical properties of <strong>HBQ</strong> were investigated in various solvents. The strong binding of <strong>HBQ</strong> to Cu<sup>2+</sup> causes a blue shift in the emission maxima and enhanced fluorescence due to reduced non-radiative decay, highlighting its selectivity for Cu<sup>2+</sup> detection. Absorption and emission spectroscopy revealed the binding interactions, sensitivity, and selectivity of <strong>HBQ</strong> toward Cu<sup>2+</sup> ions. The turn-on fluorescence of <strong>HBQ</strong> shows high sensitivity, with detection (LOD) and quantification (LOQ) limits extending to sub-micron concentrations. The sensor’s reliability and applicability were further validated using real samples, with a recovery rate of approximately 100 ± 2 %.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"333 ","pages":"Article 125853"},"PeriodicalIF":4.3000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1386142525001593","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SPECTROSCOPY","Score":null,"Total":0}
引用次数: 0

Abstract

Copper (Cu) is essential for biological systems and animal-plant tissues, but Cu2+ ions are also significant environmental pollutants. An imbalance in non-toxic Cu2+ levels can lead to health issues. This study focuses on the development of a novel fluorescent turn-on probe, 3,4-dihydrobenzo[4,5]imidazole[2,1-b]quinazoline-1(2H)-one (HBQ) for the selective and sensitive detection of Cu2+ ions. The synthesis of HBQ was achieved from the reaction of 2-((dimethylamino)methylene)-cyclohexane-1,3-dione and 2-aminobenzimidazole. The photophysical properties of HBQ were investigated in various solvents. The strong binding of HBQ to Cu2+ causes a blue shift in the emission maxima and enhanced fluorescence due to reduced non-radiative decay, highlighting its selectivity for Cu2+ detection. Absorption and emission spectroscopy revealed the binding interactions, sensitivity, and selectivity of HBQ toward Cu2+ ions. The turn-on fluorescence of HBQ shows high sensitivity, with detection (LOD) and quantification (LOQ) limits extending to sub-micron concentrations. The sensor’s reliability and applicability were further validated using real samples, with a recovery rate of approximately 100 ± 2 %.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
8.40
自引率
11.40%
发文量
1364
审稿时长
40 days
期刊介绍: Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.
期刊最新文献
Detection of Hg2+ in environmental water conditions by using a reusable SERS-based microfluidic chip with a high specificity and sensitivity A triphenylamine-based multifunctional fluorescent probe for Cu2+ and Zn2+ as well as mechanochromism and application in latent fingerprints A selective BODIPY-based fluorescent sensor for the detection of Cu2+ ions in biological and environmental samples Supramolecular interaction of ketoprofen with native and hydroxypropyl beta-cyclodextrin: Improved solubility and anti-inflammatory Phytosynthesis of anisotropic silver and gold nanoparticles: characterization and anticancer activity towards HIO180 and HeyA8 cells
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1