Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy最新文献

英文中文

Corrigendum to “Oppositely-charged silver nanoparticles enable selective SERS molecular enhancement through electrostatic interactions” [Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 322 (2024) 124852]

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-15 DOI: 10.1016/j.saa.2025.126218

Yuqing Gu , Siyi Wu , Zhewen Luo , Linley Li Lin , Jian Ye

引用次数: 0

Aliphatic amines – Sensing application in aqueous media using supramolecularly stacked acriflavine dye on graphene oxide

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-12 DOI: 10.1016/j.saa.2025.126233

Pavitra Rajendran , Jamuna Kannan , Lakshminarayanan Piramuthu , Erumaipatty Rajagounder Nagarajan , Shanmugam Sivakumar , Narayanan Selvapalam

Supramolecularly stacked acriflavine dye on graphene oxide (GO-Acy) was utilized for the first time to detect aliphatic amines, making it a highly sensitive and selective material. This method involved developing a distinctive, discriminative, and highly selective fluorescent sensor that displayed a ’turn-on’ response to aliphatic amines. The sensor probe operated through supramolecular host–guest interactions between the amines and dyes, enabling the detection of aliphatic amines. Upon the interaction of aliphatic amines with bound Acy dye on graphene oxide, the fluorescent sensor exhibited a release of Acy dyes and a rapid appearance of fluorescence. GO-Acy demonstrated high selectivity for 1,4-butanediamine (BD), exhibiting strong fluorescence intensity and accurately distinguishing it from various aliphatic amines, aromatic amines, and amino acids. The fluorescene emission intensities of GO-Acy at λ_em = 510 nm was observed after exposure to different amines, with an excitation wavelength of GO-Acy at λ_ex = 450 nm. In addition to its high selectivity, the sensor probe also exhibited excellent sensitivity towards BD, with a limit of detection (LOD) of 9.9 nM. This graphene-based material proved to be a highly effective tool for detecting aliphatic amines in aqueous media, requiring no special experiments while providing both good selectivity and sensitivity. Additionally, GO-Acy@CB[7] demonstrated diverse responses to aliphatic amines, suggesting its ability to discriminate between them through fluorescence quenching. GO-Acy has proven effective in monitoring fish products that release amine vapors during decomposition. Furthermore, test paper strips made with GO-Acy could quickly detect amines in actual fish samples, highlighting the potential of GO-Acy for food quality inspection.

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引用次数: 0

Up-conversion emission characteristics and temperature measurement of core-shell structured NaGdF4: Er3+Tm3+/Yb3+@NaYbF4: xYb3+ (x = 25, 50) phosphors

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-11 DOI: 10.1016/j.saa.2025.126223

Li Xuecheng, Hao Haoyue, Li Liang

In this study, the intensity and properties of up-conversion luminescence in core–shell structured NaGdF₄: Er³⁺/Tm³⁺/Yb³⁺@NaGdF₄: Yb³⁺ phosphors were investigated. After coating the NaGdF₄: 0.5Er³⁺/0.5Tm³⁺/30Yb³⁺ (0.5Er/0.5Tm/30Yb) core with NaGdF₄: xYb³⁺ (x = 25, 50) shells, the luminescence intensity of the phosphors was improved. The enhancement factor reached to 3.97 (x = 25) and 1.15 (x = 5) respectively. Owing to the different increase of up-conversion luminescence peak, the emission color changed from blue-green to yellowish-green in NaGdF₄: 0.5Er³⁺/0.5Tm³⁺/30Yb³⁺@NaGdF₄: 25Yb³⁺ (0.5Er/0.5Tm/30Yb@25Yb) phosphors. Additionally, the temperature sensing properties of the 0.5Er/0.5Tm/30Yb@25Yb phosphors were examined. A maximum relative sensitivity (S_r) of 0.013 K⁻¹ was observed at 303 K based on florescence intensity ratio of two green emission. And a higher S_r of 0.034 K⁻¹ was recorded at 403 K based on the ratio of green (540 nm) and near-red emissions (800 nm). These findings not only deepen the understanding of the up-conversion processes in core–shell structured phosphors but also promote the development of rare-earth ion core–shell structures for applications in temperature sensing and luminescent displays.

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引用次数: 0

A novel fluorescent probe with large stokes shift based on naphthalimide and phenanthroline for specific detection of Ag+ and its application in living cells imaging

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-11 DOI: 10.1016/j.saa.2025.126222

Chenglu Zhang, Jinghao Guo, Yang Zhang, Cui Liu

Silver ions (Ag⁺) are widely used in industry and daily life. To achieve the specific and sensitive detection of Ag⁺, a novel fluorescent probe NP based on naphthalimide-phenanthroline was developed in this study. NP has an emission wavelength of 580 nm and exhibits a large Stokes shift (190 nm), showing a quenching fluorescence response to Ag⁺. NP can sensitively detect Ag⁺ with a detection limit as low as 24.6 nM. The response time is only 110 s. In particular, NP demonstrates effective detection of Ag⁺ in real water samples. In addition, NP exhibits low toxicity and has been successfully applied for Ag⁺ imaging in Hela cells.

银离子（Ag+）被广泛应用于工业和日常生活中。为了实现对 Ag+ 的特异性和灵敏度检测，本研究开发了一种基于萘二甲酰亚胺-菲罗啉的新型荧光探针 NP。NP 的发射波长为 580 nm，并表现出较大的斯托克斯位移（190 nm），对 Ag+ 具有淬灭荧光响应。NP 可灵敏地检测 Ag+，检测限低至 24.6 nM。特别是，NP 能有效检测真实水样中的 Ag+。此外，NP 的毒性很低，已成功应用于 Hela 细胞中的 Ag+ 成像。

引用次数: 0

Developing an aurone-based colorimetric fluorescent probe for fast cysteine sensing in foods, test strips and biological imaging

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-11 DOI: 10.1016/j.saa.2025.126226

Xiaoyan Cao , Yichi Zhang , Jialing Hu , Yifan Wei , Yingyue Ding , Yanfei Kang , Chuanqing Ren , Qin Wang

Cysteine (Cys) is integral to both industrial applications and biological processes. In this study, a novel colorimetric fluorescent sensor APA, defined by its intramolecular charge transfer (ICT) properties, was optimized to effectively discriminate Cys from other structurally similar compounds such as homocysteine (Hcy) and glutathione (GSH). We present the aurone-incorporated fluorescent sensor APA, which features a 4-dimethylaminocinnamaldehyde group conjugated to the aurone scaffold and facilitates selective detection of Cys with a limit of detection (LOD) of 25.7 nM. Compared to previous studies, sensor APA exhibits near-infrared properties, a reduced reaction time of just 2 min, and a significant Stokes shift of 190 nm. Notably, APA has been successfully employed for visual imaging of Cys in test strips and quantitative detection in various food samples in real-time (including garlic, carrot, tomato, onion, green pepper, cauliflower, daikon, lotus root, apple, pear, milk powder, bread, and biscuits). Furthermore, APA has proven effective for colorimetric imaging of both endogenous and exogenous Cys in A549 cells as well as zebrafish and mice models demonstrating its practical biological applications. Overall, our findings highlight the potential of APA as one of the most promising designs for sensing Cys within the food industry and biological systems. Additionally, APA-OH serves as an ideal fluorophore for constructing fluorescence sensors aimed at bioimaging.

半胱氨酸（Cys）是工业应用和生物过程中不可或缺的物质。本研究优化了一种新型比色荧光传感器 APA，该传感器由其分子内电荷转移（ICT）特性定义，可有效区分 Cys 和其他结构相似的化合物，如同型半胱氨酸（Hcy）和谷胱甘肽（GSH）。我们展示了醛酮嵌入式荧光传感器 APA，其特点是 4-二甲基氨基肉桂醛基团与醛酮支架共轭，有利于选择性检测 Cys，检测限 (LOD) 为 25.7 nM。与之前的研究相比，传感器 APA 具有近红外特性，反应时间仅需 2 分钟，而且斯托克斯位移达到 190 纳米。值得注意的是，APA 已成功用于试纸中 Cys 的可视成像和各种食品样品（包括大蒜、胡萝卜、番茄、洋葱、青椒、花椰菜、萝卜、莲藕、苹果、梨、奶粉、面包和饼干）的实时定量检测。此外，APA 还能对 A549 细胞以及斑马鱼和小鼠模型中的内源性和外源性 Cys 进行有效的比色成像，证明了它在生物学上的实际应用。总之，我们的研究结果凸显了 APA 作为食品工业和生物系统中最有前景的 Cys 感测设计之一的潜力。此外，APA-OH 还是构建生物成像荧光传感器的理想荧光团。

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引用次数: 0

A portable platform integrated with smartphones for rapid lactic acid analysis via ratiometric fluorescent imaging 与智能手机集成的便携式平台，可通过比率荧光成像技术进行快速乳酸分析

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-11 DOI: 10.1016/j.saa.2025.126224

Wen-Ru Wu , Jing Li , Yue Lin , Fang Luo , Cui-Ying Lin , Bin Qiu , Zhen-Yu Lin , Jian Wang , Fang-Zheng Huang

This study presents a smartphone-integrated portable platform for rapid lactic acid (LA) analysis using ratiometric fluorescent imaging. The system employs a dual-emission probe composed of glutathione-modified gold nanoclusters (GSH-AuNCs) and carbon quantum dots (CDs), enabling visual detection via fluorescence color transitions under 365 nm UV excitation. As LA concentration increases, the fluorescence shifts from blue to orange. Smartphone photography and RGB color analysis reveal a nonlinear sigmoidal correlation between the red-to-blue intensity ratio (R/B) and LA concentration, modeled with a coefficient of determination (R² = 0.998). The method exhibits high selectivity and achieves recovery rates of 94.5–104.8 % in sweat samples, validated against LC-MS. This technology offers a novel, on-site solution for food quality assessment and health monitoring applications.

引用次数: 0

A lysosome-targetable multifunctional fluorescent probe based on intramolecular NH…NH2 hydrogen bonding for detection of hypochlorite and cyanides

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-10 DOI: 10.1016/j.saa.2025.126180

Aoran Kan , Yingmei Cao , Qiunan She , Yicong Zhou , Yingming Tan , Jie Yang , Jinwu Yan , Zhenjiang Liu , Chuanxiang Liu

The creation of a singular fluorescent probe for the detection of various analytes is crucial for comprehending the interactions among analytes in living cells. This study presents a novel multifunctional fluorescent probe, designated Lyso-Nap-Py, which utilizes distinctive intramolecular NH^…NH₂ hydrogen bonding for the simultaneous detection of hypochlorite and cyanides within living cells. This probe demonstrates the ability to detect cyanides and hypochlorite, offering advantages including high selectivity, fluorescence turn-off at 638 nm, a low limit of detection, and rapid response times. The Lyso-Nap-Py-immobilized test papers demonstrated notable reversible colorimetric changes observable to the naked eye in response to fluctuations in environmental acidity and basicity, showcasing over four cycles of reversibility. The interactions of Lyso-Nap-Py with cyanides and HClO lead to alterations in emissions within the red channels, yielding specific signal responses to various analytes present in cellular lysosomes. Significantly, through the utilization of this singular probe, we accomplished the imaging of exogenous cyanides and hypochlorite, in addition to endogenous hypochlorite, within living cells and zebrafish. Furthermore, the advantageous features of probes that utilize intramolecular NH^…NH₂ hydrogen bonding demonstrate considerable promise for their use in cellular imaging within lysosomes.

建立一个用于检测各种分析物的单一荧光探针对于理解分析物在活细胞中的相互作用至关重要。本研究提出了一种新型多功能荧光探针（命名为 Lyso-Nap-Py），它利用独特的分子内 NH...NH2 氢键同时检测活细胞内的次氯酸盐和氰化物。该探针能够检测氰化物和次氯酸盐，具有选择性高、在 638 纳米波长处荧光熄灭、检测限低和响应速度快等优点。溶菌酶-Nap-Py 固定化试纸在环境酸碱度波动时表现出肉眼可观察到的显著可逆比色变化，显示出超过四个周期的可逆性。Lyso-Nap-Py 与氰化物和 HClO 的相互作用导致红色通道内的发射发生变化，从而对细胞溶酶体中的各种分析物产生特定的信号反应。值得注意的是，通过使用这种单一探针，除了内源性次氯酸盐外，我们还完成了活细胞和斑马鱼体内外源性氰化物和次氯酸盐的成像。此外，利用分子内 NH...NH2 氢键的探针的优势特点也为其在溶酶体内的细胞成像中的应用展示了广阔的前景。

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引用次数: 0

Morphology evolution and NIR-II luminescence enhancement in LaF3:Er3+ nanoparticles

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-10 DOI: 10.1016/j.saa.2025.126198

Puyan Hao, Tingting Li, Jiahui Ren, Rui Zhu, Mengzhen Jia, Yu Dong, Mandong Zhai, Xinyu Song, Xiaoqi Zhao

Luminescence imaging in the second near-infrared (NIR-II) window (1000–1700 nm) has attracted extensive attention in recent years owing to its superior tissue penetration ability and weak spontaneous fluorescence effects in biological tissues. However, an important bottleneck restricting the development of NIR-II luminescence imaging technology is the lack of nanoprobes with suitable morphology, particle size and high luminescence intensity. In this work, NIR-II emitted LaF₃:Er³⁺ nanoparticles (NPs) were synthesized by a simple chemical precipitation method, where the size and morphology of LaF₃:Er³⁺ NPs were precisely controlled through the regulation of reaction conditions. The NIR-II luminescence of Er³⁺ was effectively enhanced for 8.4 times by Zr⁴⁺ doping. The results provides useful reference for the research of NIR-II luminescent imaging nanoprobes.

引用次数: 0

Intermediate data fusion improves the accuracy of near-infrared spectroscopy and Raman spectroscopy for the detection of aflatoxin B1 in peanuts

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-09 DOI: 10.1016/j.saa.2025.126216

CongLi Mei , Jihong Deng , Jian Li , Hui Jiang

This study developed a convolutional neural network (CNN) model based on feature-level data fusion for quantitatively detecting aflatoxin B1 (AFB1) in peanuts. Using a portable near-infrared (NIR) spectrometer and a Raman spectrometer, NIR and Raman spectra were collected from peanut samples with varying levels of fungal contamination. The spectral data were then enhanced and preprocessed, and individual CNN models were constructed for each type of spectrum. Building on the single-spectrum models, data-level and feature-level fusion of the NIR and Raman spectra were performed, and corresponding CNN models were developed for the quantitative detection of AFB1 in peanuts. Experimental results demonstrated that the CNN models with data fusion significantly improved detection performance and generalization ability compared to single-spectrum CNN models, particularly those using feature-level fusion. The feature-level fusion CNN model yielded the best performance, with a root mean square error of prediction of 19.7787 μg·kg⁻¹, a prediction correlation coefficient of 0.9836 for test set 1 (containing augmented spectra), and 0.9890 for test set 2 (containing only raw spectra), with a relative prediction deviation of 7.6506. Overall, this study demonstrated the superiority of data fusion and the feasibility of applying CNNs in spectral detection, providing a reference for quantitatively detecting mycotoxins.

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引用次数: 0

Lipoic acid assisted microwave based synthesis of Au-Ag nanoclusters with tunable fluorescence for antimicrobial and bioimaging applications

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Pub Date : 2025-04-09 DOI: 10.1016/j.saa.2025.126212

Deepika Sharma , Rohit Sharma , Pankaj Sharma , Nishima Wangoo , Rohit K. Sharma

This study reports on the pioneering synthesis and application of monometallic lipoic acid (LA) stabilized gold nanoclusters (LA@AuNCs) and bimetallic gold-silver nanoclusters (LA@Au-AgNCs) fabricated via a novel microwave-assisted method. The synthesis process unveils a significant augmentation in the quantum yield of LA@AuAgNCs up to 7.9-fold compared to their monometallic counterparts (LA@Au NCs), showcasing the efficacy of the novel microwave-assisted fabrication methodology. The rapid synthesis facilitated by microwave heating not only ensures efficiency but also contributes to superior optical properties. Additionally, the strategic modulation of exogenous parameters, such as thermal conditions and ionic metal concentrations, was leveraged to meticulously engineer the nanocluster surface characteristics, facilitating the procurement of tunable photoluminescent emission spectra spanning from 650 to 800 nm. The applicability of the synthesized metallic nanoclusters has been rigorously evaluated, demonstrating their efficacy as a dual-functional therapeutic agent. Primarily, their antimicrobial properties are pronounced against both Gram-positive and Gram-negative bacterial strains, attributed to the ultrasmall dimensions of the synthesized nanoclusters. Also, these intrinsically fluorescent metallic nanoclusters were employed as advanced bioimaging probes for the precise labelling and visualization of bacterial cells.

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引用次数: 0

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