Risk factors for distant metastasis in papillary thyroid carcinoma: Association with lateral lymph node metastasis

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY Auris Nasus Larynx Pub Date : 2025-02-11 DOI:10.1016/j.anl.2025.01.008

Masataka Nakamura , Nobuya Monden , Tomonori Terada , Nobuhiro Uwa , Yuichiro Shinoda , Junko Fukutake , Hiroshi Kono , Takehito Kishino , Naoki Akisada , Yuji Hayashi , Kenzo Tsuzuki

{"title":"Risk factors for distant metastasis in papillary thyroid carcinoma: Association with lateral lymph node metastasis","authors":"Masataka Nakamura , Nobuya Monden , Tomonori Terada , Nobuhiro Uwa , Yuichiro Shinoda , Junko Fukutake , Hiroshi Kono , Takehito Kishino , Naoki Akisada , Yuji Hayashi , Kenzo Tsuzuki","doi":"10.1016/j.anl.2025.01.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to clarify the characteristics of distant metastasis in patients with N1a and N1b papillary thyroid carcinoma (PTC) and the significance of lateral lymph node metastasis as a risk factor for distant metastasis.</div></div><div><h3>Methods</h3><div>Of the 537 patients with N1a and N1b PTC who underwent surgical treatment at Hyogo Medical University from January 2013 to December 2020 and Shikoku Cancer Center from January 2007 to December 2018, 283 (79 men and 204 women) with lymph node metastasis were analyzed in this study. The median age was 58 (range, 19–93) years, and the median observation period was 73 (range, 1–152) months after surgery.</div></div><div><h3>Results</h3><div>The incidence rate of distant metastasis was higher when metastases were detected at levels II or V. Multivariate analysis revealed that the factors that significantly increased the distant metastasis rate were age ≥ 55 years (<em>p</em> = 0.011), tumor size > 4 cm (<em>p</em> = 0.034), and lymph node metastasis at levels II and V (<em>p</em> = 0.034).</div></div><div><h3>Conclusions</h3><div>For patients with N1b metastasis, specifically at levels II or V, total thyroidectomy with lateral neck dissection should be considered the primary choice for postoperative radioactive iodine therapy.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 174-178"},"PeriodicalIF":1.6000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Auris Nasus Larynx","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0385814625000070","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This study aimed to clarify the characteristics of distant metastasis in patients with N1a and N1b papillary thyroid carcinoma (PTC) and the significance of lateral lymph node metastasis as a risk factor for distant metastasis.

Methods

Of the 537 patients with N1a and N1b PTC who underwent surgical treatment at Hyogo Medical University from January 2013 to December 2020 and Shikoku Cancer Center from January 2007 to December 2018, 283 (79 men and 204 women) with lymph node metastasis were analyzed in this study. The median age was 58 (range, 19–93) years, and the median observation period was 73 (range, 1–152) months after surgery.

Results

The incidence rate of distant metastasis was higher when metastases were detected at levels II or V. Multivariate analysis revealed that the factors that significantly increased the distant metastasis rate were age ≥ 55 years (p = 0.011), tumor size > 4 cm (p = 0.034), and lymph node metastasis at levels II and V (p = 0.034).

Conclusions

For patients with N1b metastasis, specifically at levels II or V, total thyroidectomy with lateral neck dissection should be considered the primary choice for postoperative radioactive iodine therapy.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Auris Nasus Larynx 医学-耳鼻喉科学

CiteScore

3.40

自引率

5.90%

发文量

169

审稿时长

30 days

期刊介绍： The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science. Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed. Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.