Off-label LAI antipsychotics effective for treating bipolar disorder in teens

Alison Knopf
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Abstract

Treating adolescents with long-acting injectable (LAI) antipsychotics which are approved for adults is an effective solution to nonadherence to oral medications, researchers have found. Oral antipsychotics are approved for mania, but adherence is often poor for various reasons, including aversion to side effects, cognitive dysfunction, impulsivity, anosognosia, and substance use. For adolescents with bipolar mania or schizoaffective disorder, the conditions these medications are approved for in adults, the LAI antipsychotics show that bipolar mania in adolescents is effectively treated based on Young Mania Rating Scale (YMRS) assessments.

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标签外LAI抗精神病药物对治疗青少年双相情感障碍有效
研究人员发现,使用已批准用于成人的长效注射(LAI)抗精神病药物治疗青少年是解决口服药物不依从性的有效方法。口服抗精神病药物被批准用于治疗躁狂症,但由于各种原因,包括对副作用的厌恶、认知功能障碍、冲动、病感失认症和药物使用,依从性往往很差。对于患有双相躁狂症或分裂情感障碍的青少年,这些药物已被批准用于成人,LAI抗精神病药物显示,基于青少年躁狂症评定量表(YMRS)评估,青少年双相躁狂症得到有效治疗。
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