Biomarkers of Inflammation Associated with Radon Exposure in the School Inner-City Asthma Study (SICAS).

IF 11.4 1区医学 Q1 ALLERGY Journal of Allergy and Clinical Immunology Pub Date : 2025-02-07 DOI:10.1016/j.jaci.2025.01.033

Tina M Banzon, Youn Soo Jung, Kimberly F Greco, Longxiang Li, Kari Nadeau, Perdita Permaul, Petros Koutrakis, Jonathan M Gaffin, Wanda Phipatanakul

{"title":"Biomarkers of Inflammation Associated with Radon Exposure in the School Inner-City Asthma Study (SICAS).","authors":"Tina M Banzon, Youn Soo Jung, Kimberly F Greco, Longxiang Li, Kari Nadeau, Perdita Permaul, Petros Koutrakis, Jonathan M Gaffin, Wanda Phipatanakul","doi":"10.1016/j.jaci.2025.01.033","DOIUrl":null,"url":null,"abstract":"Background: Radon is an omnipresent radioactive gas recently reported to be associated with increased asthma morbidity.Objective: We aimed to identify biomarkers associated with radon exposure and hypothesized elevated radon exposure to be associated with increased inflammatory biomarker levels in an exploratory analysis.Methods: In 137 schoolchildren with asthma in the School Inner-City Asthma Study, we assessed estimated radon exposure (1-month averaged radon) by a spatiotemporal model and 46 inflammatory biomarker outcomes, adjusting for co-pollutants (PM2.5, NO2, O3) and performed mixed effect regression analysis. Causal mediation analysis was used to determine the association between radon exposure and absolute eosinophil count.Results: In a total of 137 observations, we found a positive association with radon exposure and interleukin-5 (IL-5), a TH2 cytokine known to recruit eosinophils to asthmatic airways. Higher radon was significantly associated with a greater increase in IL-5 compared to low radon exposure (obs=137; 1-month moving radon average [RR=1.134, 95% CI 1.004 - 1.280; p=0.044]). Mediation analysis revealed an indirect effect of IL-5 (β=0.006, 95% CI 0.001 - 0.012; p=0.024) on the association between radon exposure and absolute eosinophil count. This suggests the effect of radon on eosinophil count is mediated through IL-5.Conclusions: Radon is a potential novel, modifiable risk factor for asthma recently reported to be associated with asthma morbidity. This work identifies important biological disease pathways via biomarkers that may be central to the exposure-outcome relationship.","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Allergy and Clinical Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jaci.2025.01.033","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Radon is an omnipresent radioactive gas recently reported to be associated with increased asthma morbidity.

Objective: We aimed to identify biomarkers associated with radon exposure and hypothesized elevated radon exposure to be associated with increased inflammatory biomarker levels in an exploratory analysis.

Methods: In 137 schoolchildren with asthma in the School Inner-City Asthma Study, we assessed estimated radon exposure (1-month averaged radon) by a spatiotemporal model and 46 inflammatory biomarker outcomes, adjusting for co-pollutants (PM_2.5, NO₂, O₃) and performed mixed effect regression analysis. Causal mediation analysis was used to determine the association between radon exposure and absolute eosinophil count.

Results: In a total of 137 observations, we found a positive association with radon exposure and interleukin-5 (IL-5), a TH₂ cytokine known to recruit eosinophils to asthmatic airways. Higher radon was significantly associated with a greater increase in IL-5 compared to low radon exposure (obs=137; 1-month moving radon average [RR=1.134, 95% CI 1.004 - 1.280; p=0.044]). Mediation analysis revealed an indirect effect of IL-5 (β=0.006, 95% CI 0.001 - 0.012; p=0.024) on the association between radon exposure and absolute eosinophil count. This suggests the effect of radon on eosinophil count is mediated through IL-5.

Conclusions: Radon is a potential novel, modifiable risk factor for asthma recently reported to be associated with asthma morbidity. This work identifies important biological disease pathways via biomarkers that may be central to the exposure-outcome relationship.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Allergy and Clinical Immunology 医学-过敏

CiteScore

25.90

自引率

7.70%

发文量

1302

审稿时长

38 days

期刊介绍： The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.