Collision tumor consisting of primary mucoepidermoid carcinoma and adenocarcinoma in the lung: a case report and literature review.

IF 1.1 4区医学 Q3 PATHOLOGY Medical Molecular Morphology Pub Date : 2025-12-01 Epub Date: 2025-02-10 DOI:10.1007/s00795-025-00422-6

Xiaomin Dai, Ruixia Xie, Linggong Zeng, Fang Peng

引用次数: 0

Abstract

Mucoepidermoid carcinoma in the lung is uncommon, while the occurrence of a collision tumor consisting of primary mucoepidermoid carcinoma (MEC) and typical adenocarcinoma is extremely rare. We report a case of a 70-year-old female with the presence of a nodule in her right lung. The pathological examination revealed a primary collision tumor consisting of invasive adenocarcinoma and mucoepidermoid carcinoma. Manual microdissection was performed to selectively isolate the MEC and adenocarcinoma components, followed by exome sequencing which unveiled identical mutations in both components, suggesting their monoclonal origins with divergent differentiation. Clinical awareness and recognition of such collision tumors are crucial, as they will determine appropriate treatment strategies based on the individual biological aggressiveness of each tumor component.

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肺原发性黏液表皮样癌与腺癌的碰撞瘤1例报告并文献复习。

肺黏液表皮样癌并不常见，而由原发性黏液表皮样癌（MEC）和典型腺癌组成的碰撞肿瘤的发生极为罕见。我们报告一例70岁的女性与存在的结节在她的右肺。病理检查显示为侵袭性腺癌和黏液表皮样癌组成的原发性碰撞瘤。人工显微解剖选择性分离MEC和腺癌成分，然后进行外显子组测序，发现这两个成分具有相同的突变，表明它们的单克隆起源具有不同的分化。临床意识和识别这种碰撞肿瘤是至关重要的，因为他们将根据每个肿瘤成分的个体生物侵袭性确定适当的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.