{"title":"Cutting to the chase: Pruning alloreactive T cells","authors":"Anita S. Chong, Marlena Habal","doi":"10.1016/j.immuni.2025.01.005","DOIUrl":null,"url":null,"abstract":"Indirect CD4<sup>+</sup> T cell allorecognition of donor peptides presented by host MHC class II antigens contributes to transplant rejection in part by eliciting donor-specific antibodies (DSAs). In this issue of <em>Immunity</em>, Zhanzak et al. revisit the role of indirectly alloreactive CD4<sup>+</sup> T cells in transplantation and demonstrate that immunodominant epitopes stimulate a narrow repertoire of T cells that can be pruned to prevent DSA formation.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"41 1","pages":""},"PeriodicalIF":25.5000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.immuni.2025.01.005","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Indirect CD4+ T cell allorecognition of donor peptides presented by host MHC class II antigens contributes to transplant rejection in part by eliciting donor-specific antibodies (DSAs). In this issue of Immunity, Zhanzak et al. revisit the role of indirectly alloreactive CD4+ T cells in transplantation and demonstrate that immunodominant epitopes stimulate a narrow repertoire of T cells that can be pruned to prevent DSA formation.
期刊介绍：
Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.
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