Crosslinked polyacrylamide stabilized Cu(I) catalyst for efficient synthesis of 1,2,3-triazoles via click reactions

Abstract

The stability of crosslinked polyacrylamide and its ability to be modified for use in a variety of applications make it an excellent support material in heterogeneous systems. Herein, we report a novel catalyst derived from copper(I)-Schiff base complex and its immobilization into crosslinked polyacrylamide which was synthesized by a two-step process, followed by the fixation of copper(I) (CPAM_SL@CuI). Various techniques were used to characterize the developed polymeric copper(I) catalyst.These methods included FTIR, ICP, DR-UV–vis., FTIR, XRD, FE-SEM, EDAX, TEM, TG/DTGA, and elemental analysis. The CPAM anchored copper(I) Schiff base complex demonstrated remarkably high catalytic activity in heterogeneous three-component click reactions of alkyl or benzyl halides, sodium azide, and terminal alkynes in water at room temperature with a low catalyst loading without adding any additives yielding 1,4-disubstituted 1,2,3-triazoles without generating any waste. Furthermore, the newly developed polymeric copper(I) catalyst could be recovered and reused six consecutive times without significantly reducing the reaction yield.