Genetic Predictive Association Between Inflammatory Cytokines and Vitiligo: A Bidirectional Mendelian Randomization Study

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of Clinical Practice Pub Date : 2025-02-12 DOI:10.1155/ijcp/1093015

Tianbing Lei, Yao Ni

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Abstract

Background: Previous studies have indicated a close association between vitiligo and inflammatory cytokines, yet the genetic predictive association remains unclear. The study aimed to predict the relationship between vitiligo and inflammatory cytokines in genetics.

Methods: A bidirectional analysis was conducted by the two-sample MR. We selected independent genetic tools for significant levels associated with inflammatory cytokines and vitiligo from corresponding meta-analyses of genome-wide association study (GWAS). The summary data for inflammatory cytokines were derived from a GWAS meta-analysis conducted on three separate Finnish population cohorts, comprising a total of 8293 individuals (N = 8293). The vitiligo data, on the other hand, were extracted from a GWAS meta-analysis conducted on individuals of European ancestry, totaling 44,266 individuals (N = 44,266). As the primary analytical approach, we employed the inverse variance weighted (IVW) method, and to ensure the reliability of our main findings, we also performed sensitivity analysis to evaluate the robustness.

Results: Compelling evidence indicated a causal association between genetically predicted IL-18 and IL-8 with vitiligo (odds ratio, OR: 1.162, 95% CI: 1.043–1.295, p = 0.006, and p_fdr = 0.020 and OR: 0.726, 95% CI: 0.602–0.876, p = 0.001, and p_fdr = 0.004). In addition, cytokines including stromal cell-derived factor-1 alpha (SDF1a) (Beta: 0.032, p = 0.016, and p_fdr = 0.039), IL-17 (Beta: 0.038, p = 0.005, and p_fdr = 0.027), basic fibroblast growth factor (FGFBasic) (Beta: 0.028, p = 0.034, and p_fdr = 0.170), monocyte chemoattractant protein-1(MCP1) (Beta: 0.026, p = 0.046, and p_fdr = 0.189), and platelet-derived growth factor BB (PDGFbb) (Beta: 0.026, p = 0.040, and p_fdr = 0.198) were suggested to be the consequences of vitiligo.

Conclusions: According to this investigation, it has been proposed that the etiology of vitiligo is likely associated with IL-18 and IL-8, whereas the downstream progression of vitiligo can be attributed to several inflammatory cytokines such as IL-17, SDF1a, PDGFbb, MCP1, and FGFBasic.

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.