Research progress in unilateral moyamoya disease.

IF 2.7 3区医学 Q3 NEUROSCIENCES Frontiers in Human Neuroscience Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI:10.3389/fnhum.2025.1503639

Xiaokuan Hao, Cunxin Tan, Ziqi Liu, Yang Tie, Yanru Wang, Shihao He, Ran Duan, Rong Wang

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Abstract

Unilateral moyamoya disease (U-MMD) is a chronic vascular disease characterized by progressive stenosis and occlusion of the terminal end of the internal carotid artery and its main branches, resulting in the appearance of moyamoya-like blood vessels at the base of the brain. The etiology of U-MMD is unknown, it accounts for 9.7-17.8% of all moyamoya disease, and the family incidence is 5.5-13.3%. The clinical characteristics are similar to those of typical moyamoya disease, but there are some differences. U-MMD can progress to bilateral moyamoya disease with a median probability of 29.01% (ranging from 6.3 to 58.8%), and there are many risk factors that promote its development. Surgical treatment can effectively reduce the incidence of ischemic stroke and improve prognosis. However, the timing and indications for surgery require further investigation. This article reviews the latest research progress on the etiology, epidemiology, clinical and radiological characteristics, progression, treatment, and prognosis of U-MMD.

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单侧烟雾病的研究进展。

单侧烟雾病（U-MMD）是一种慢性血管疾病，其特征是颈内动脉及其主要分支的终末进行性狭窄和闭塞，导致脑底部出现烟雾样血管。u -烟雾病病因不明，占所有烟雾病的9.7-17.8%，家族发病率为5.5-13.3%。临床特征与典型的烟雾病相似，但又有一定的差异。U-MMD可发展为双侧烟雾病，中位概率为29.01%（范围为6.3 ~ 58.8%），促进其发展的危险因素较多。手术治疗可有效降低缺血性脑卒中的发生率，改善预后。然而，手术的时机和适应症需要进一步研究。本文综述了烟雾病的病因、流行病学、临床和放射学特征、进展、治疗和预后等方面的最新研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Human Neuroscience 医学-神经科学

CiteScore

4.70

自引率

6.90%

发文量

830

审稿时长

2-4 weeks

期刊介绍： Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.