Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes.

IF 2.2 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S502333

Tanat Yongpisarn, Kunlawat Thadanipon, Poonkiat Suchonwanit, Ploysyne Rattanakaemakorn

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Abstract

Background: Psoriasis is an immune-mediated skin disease with a chronic relapsing-remitting course. Hyperglycemia has been shown to correlate with psoriasis severity. However, whether it could trigger psoriasis flares is not known.

Objective: To investigate the association between hyperglycemia and psoriasis exacerbation.

Methods: We conducted a retrospective cohort study at a university-affiliated hospital in Bangkok, Thailand, between 2008 and 2022 to examine the effects of elevated HbA1c on psoriasis flares. Patients with psoriasis vulgaris and either type 2 diabetes mellitus (T2DM) or impaired fasting glucose (IFG) who had at least 2 HbA1c values were identified. Statistical analyses were performed using mixed-effects logistic regression.

Results: A total of 201 psoriasis patients (95 with severe psoriasis and 106 with mild psoriasis) with 1,717 follow-up visits were included in the analysis. In patients with severe psoriasis, HbA1c ≥ 7% (adjusted odds ratio (OR): 1.905 (95% confidence interval: 1.328-2.731)) and alcohol consumption status (adjusted OR: 3.328 (1.235-8.965)) were identified as independent prognostic factors for psoriasis flares. Meanwhile, in mild psoriasis patients, none of the variables were independently associated with psoriasis flares.

Conclusion: Hyperglycemia and alcohol consumption were associated with exacerbation in patients with severe psoriasis who had T2DM/IFG.

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高血糖是糖尿病或糖尿病前期重症银屑病病情加重的潜在预后因素

背景：银屑病是一种具有慢性复发-缓解过程的免疫介导的皮肤病。高血糖已被证明与牛皮癣的严重程度相关。然而，它是否会引发牛皮癣尚不清楚。目的：探讨高血糖与银屑病加重的关系。方法：2008年至2022年间，我们在泰国曼谷的一家大学附属医院进行了一项回顾性队列研究，以研究HbA1c升高对牛皮癣发作的影响。寻常型牛皮癣合并2型糖尿病（T2DM）或空腹血糖受损（IFG）且HbA1c值至少为2的患者被确定。采用混合效应逻辑回归进行统计分析。结果：共纳入201例银屑病患者（重度银屑病95例，轻度银屑病106例），随访1717次。在严重牛皮癣患者中，HbA1c≥7%（校正优势比（OR）： 1.905(95%可信区间：1.328-2.731)）和饮酒状况（校正优势比：3.328(1.235-8.965)）被确定为牛皮癣发作的独立预后因素。同时，在轻度牛皮癣患者中，没有一个变量与牛皮癣发作独立相关。结论：高血糖和饮酒与伴有T2DM/IFG的严重银屑病患者的加重有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.