Cobalt/Salox‐catalyzed Stereoselective C‐H Functionalization: Enantioselective Construction of Axially Chiral Cyclic Phosphinamides with P‐Stereogenic Center
{"title":"Cobalt/Salox‐catalyzed Stereoselective C‐H Functionalization: Enantioselective Construction of Axially Chiral Cyclic Phosphinamides with P‐Stereogenic Center","authors":"Bo Jiang, Hui Wang, Xiaobin Sun, Yiyang Qiao, Xiufang Xu, Zhiwei Miao","doi":"10.1002/adsc.202500021","DOIUrl":null,"url":null,"abstract":"We describe a novel cobalt/salicyloxazoline (Salox) catalytic system for enantioselective C‐H functionalization, enabling the synthesis of P‐stereogenic and axially chiral cyclic phosphinic amides. Chiral Salox ligands, conveniently prepared in a single step from salicylonitriles and chiral amino alcohols, facilitated this transformation with excellent enantioselectivities (92‐99% ee) and moderate to good yields (31 examples, 45‐89%). Mechanistic studies implicate a cobalt (III/IV/II) catalytic cycle in the C‐H annulation process, providing valuable insights into the stereoselective reaction pathway.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"6 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202500021","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
We describe a novel cobalt/salicyloxazoline (Salox) catalytic system for enantioselective C‐H functionalization, enabling the synthesis of P‐stereogenic and axially chiral cyclic phosphinic amides. Chiral Salox ligands, conveniently prepared in a single step from salicylonitriles and chiral amino alcohols, facilitated this transformation with excellent enantioselectivities (92‐99% ee) and moderate to good yields (31 examples, 45‐89%). Mechanistic studies implicate a cobalt (III/IV/II) catalytic cycle in the C‐H annulation process, providing valuable insights into the stereoselective reaction pathway.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
