Thermo- and pH responsive core–shell nanogels: Easy method of synthesis, properties and its use for the loading and releasing of organotin(IV) compounds

IF 5.8 2区化学 Q1 POLYMER SCIENCE European Polymer Journal Pub Date : 2025-02-10 DOI:10.1016/j.eurpolymj.2025.113822

Luis Alfonso Valdez-Olea , María Alejandra González-Urías , Angel Licea-Claveríe , Mirian A. González-Ayón , Alejandro Ramírez-Jiménez

{"title":"Thermo- and pH responsive core–shell nanogels: Easy method of synthesis, properties and its use for the loading and releasing of organotin(IV) compounds","authors":"Luis Alfonso Valdez-Olea , María Alejandra González-Urías , Angel Licea-Claveríe , Mirian A. González-Ayón , Alejandro Ramírez-Jiménez","doi":"10.1016/j.eurpolymj.2025.113822","DOIUrl":null,"url":null,"abstract":"<div><div>In this work, multicomponent responsive core–shell nanogels, based on crosslinked 2-(<em>N,N-</em>diethylamino) ethyl methacrylate (DEAEMA), homo- or copolymerized with <em>N</em>-vinylcaprolactam (NVCL), as the core, and poly(ethylene glycol) methyl ether methacrylate (PEGMA, <em>Mn</em>=950 g mol<sup>-1</sup>) as the shell, were synthesized by the Surfactant-Free Emulsion Polymerization (SFEP). Thermo- and pH responsive behavior was revealed by Dynamic Light Scattering (DLS) measurements showing nanogel expansion by decreasing pH and nanogel contraction by increasing temperature taking as reference normal physiological conditions. Nanogels composition was calculated by <sup>1</sup>H NMR, <em>D<sub>h</sub></em> was measured by DLS, thermal transitions were determined by Differential Scanning Calorimetry (DSC). The systems with the best properties were selected for the loading and releasing of diorganotin(IV) complexes which have demonstrated cytotoxic activity against different cancer cells lines. Results showed that the systems have the potential to be used as nanocarriers of metallodrugs towards cancer tissues.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"228 ","pages":"Article 113822"},"PeriodicalIF":5.8000,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Polymer Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014305725001107","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

In this work, multicomponent responsive core–shell nanogels, based on crosslinked 2-(N,N-diethylamino) ethyl methacrylate (DEAEMA), homo- or copolymerized with N-vinylcaprolactam (NVCL), as the core, and poly(ethylene glycol) methyl ether methacrylate (PEGMA, Mn=950 g mol^-1) as the shell, were synthesized by the Surfactant-Free Emulsion Polymerization (SFEP). Thermo- and pH responsive behavior was revealed by Dynamic Light Scattering (DLS) measurements showing nanogel expansion by decreasing pH and nanogel contraction by increasing temperature taking as reference normal physiological conditions. Nanogels composition was calculated by ¹H NMR, D_h was measured by DLS, thermal transitions were determined by Differential Scanning Calorimetry (DSC). The systems with the best properties were selected for the loading and releasing of diorganotin(IV) complexes which have demonstrated cytotoxic activity against different cancer cells lines. Results showed that the systems have the potential to be used as nanocarriers of metallodrugs towards cancer tissues.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

European Polymer Journal 化学-高分子科学

CiteScore

9.90

自引率

10.00%

发文量

691

审稿时长

23 days

期刊介绍： European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.