Bis-tetraarylimidazole macrocycle: An effective fluorescent sensor for folic acid

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2025-02-08 DOI:10.1016/j.dyepig.2025.112691

Ling Zheng , Xinyao Chen , Liangbin Lin , Hongyu Guo , Fafu Yang

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Abstract

Folic acid (FA) is an essential vitamin. The development of rapid, simple and on-site detecting method on FA is of great importance to human's health and industrial production. In this work, a bis-tetraarylimidazole macrocycle (BTM) was designed and synthesized as an effective fluorescent sensor for FA. The weak purple fluorescence of BTM was transferred to strong blue fluorescence after sensing FA with high sensing selectivity among 31 kinds of biomolecules and 16 kinds of ions. The limit of detection was as low as 1.06 × 10⁻⁷ M, which was the competitive one among the reported fluorescence sensors. The sensing mechanism was deduced that FA was included in the cavity of BTM based on the multiple hydrogen-bonding actions and aromatic π-π stacking interaction. The intermolecular rotating restriction and the interruption of Dexter electron transfer after binding FA were responsible for the fluorescence enhancement. This sensing ability of BTM for FA was applied on test paper, seal experiment and stimulated samples, suggesting the good qualitative and quantitative detecting ability for FA with rapid, simple and on-site procedure in real environment.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.