Identification of a Novel HIV-1 Recombinant Form Comprising CRF01_AE and Subtype C in Hebei Province, China.

IF 0.8 4区医学 Q4 IMMUNOLOGY Current HIV Research Pub Date : 2025-02-06 DOI:10.2174/011570162X369438250131065639

Yapeng Guan, Jun Wang, Xinli Lu

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引用次数: 0

Abstract

Background: Circulating recombinant form (CRF) 01_AE and subtype C are two HIV-1 subtypes. In recent years, novel HIV-1 recombinant forms have become more and more prevalent in China; however, new HIV-1 CRF01_AE/C recombinant forms are less prevalent nationwide.

Objective: Our research study aimed to investigate new recombinant forms between different HIV-1 subtypes and evaluate their transmission risk among men who have sex with men (MSM) in Hebei, China.

Method: The near full-length genome (NFLG) of HIV-1 was identified using the analyses of the phylogenetic tree and gene breakpoints.

Results: In the present work, we have reported a novel HIV-1 recombinant form composed of CRF01_AE and subtype C. The NFLG of this CRF01_AE/C form contained eight gene subregions, with four subtype C gene segments inserted into the CRF01_AE backbone, consisting of I CRF01_AE (790-1,171 nt), Ⅱ subtype C (1,172-1,840 nt), Ⅲ CRF01_AE (1,841-5,089 nt), Ⅳ subtype C (5,090-5,666 nt), Ⅴ CRF01_AE (5,667-6,317 nt), Ⅵ subtype C (6,318-8,586 nt), Ⅶ CRF01_AE (8,587-9,246 nt), and Ⅷ subtype C (9,247-9,409 nt). This new recombinant form was named CRF140_0107.

Conclusion: The study suggested that it is important to monitor HIV-1 diversity to reduce HIV- 1 transmission in China.

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.