Identification of a Novel HIV-1 Recombinant Form Comprising CRF01_AE and Subtype C in Hebei Province, China.

IF 1 4区医学 Q4 IMMUNOLOGY Current HIV Research Pub Date : 2025-01-01 DOI:10.2174/011570162X369438250131065639

Yapeng Guan, Jun Wang, Xinli Lu

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Abstract

Background: Circulating recombinant form (CRF) 01_AE and subtype C are two HIV-1 subtypes. In recent years, novel HIV-1 recombinant forms have become more and more prevalent in China; however, new HIV-1 CRF01_AE/C recombinant forms are less prevalent nationwide.

Objective: Our study aimed to investigate new recombinant forms between different HIV-1 subtypes and evaluate their transmission risk among men who have sex with men (MSM) in Hebei, China.

Methods: The near full-length genome (NFLG) of HIV-1 was identified using the analyses of the phylogenetic tree and gene breakpoints.

Results: In the present work, we have reported a novel HIV-1 recombinant form composed of CRF01_AE and subtype C. The NFLG of this CRF01_AE/C form contained eight gene subregions, with four subtype C gene segments inserted into the CRF01_AE backbone, consisting of I CRF01_AE (790-1,171 nt), Ⅱ subtype C (1,172-1,840 nt), Ⅲ CRF01_AE (1,841-5,089 nt), Ⅳ subtype C (5,090-5,666 nt), Ⅴ CRF01_AE (5,667-6,317 nt), Ⅵ subtype C (6,318-8,586 nt), Ⅶ CRF01_AE (8,587-9,246 nt), and Ⅷ subtype C (9,247-9,409 nt). This new recombinant form was identified as CRF140_0107.

Conclusion: The study suggested that it is important to monitor HIV-1 diversity to reduce HIV- 1 transmission in China.

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一种包含CRF01_AE和C亚型的新型HIV-1重组形式在河北省的鉴定

背景：循环重组形式（CRF） 01_AE和C亚型是HIV-1的两种亚型。近年来，新型HIV-1重组病毒在中国越来越流行；然而，新的HIV-1 CRF01_AE/C重组形式在全国范围内不太普遍。目的：研究HIV-1不同亚型之间的新重组形式，并评估其在河北省男男性行为者（MSM）中的传播风险。方法：利用系统发育树和基因断点分析，鉴定HIV-1近全长基因组（NFLG）。结果:在目前的工作中，我们报道了一种由CRF01_AE和C亚型组成的新型HIV-1重组形式。该CRF01_AE/C形式的NFLG包含8个基因亚区，其中4个亚型C基因片段插入CRF01_AE骨干，包括I CRF01_AE (790-1,171 nt)，Ⅱ亚型C (1,172-1,840 nt)，ⅢCRF01_AE (1,841-5,089 nt)，Ⅳ亚型C (5,090-5,666 nt)，ⅤCRF01_AE (5,667-6,317 nt)，Ⅵ亚型C (6,318-8,586 nt)，ⅦCRF01_AE （8,587-9,246 nt）和Ⅷ亚型C （9,247-9,409 nt）。这种新的重组形式被命名为CRF140_0107。结论：监测HIV-1多样性对减少HIV-1在中国的传播具有重要意义。

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.