Gabriela Parolin Trindade, Guilherme Perez Pinheiro, Alex Aparecido Rosini Silva, Andréia de Melo Porcari, Alexandra Christine Helena Frankland Sawaya
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引用次数: 0
Abstract
Lippia origanoides Kunth is a perennial shrub widely used in Brazilian folk medicine while extracts of its leaves have been shown to possess several therapeutic properties. We investigated this species' non-volatile compounds through a LC-MS-based untargeted metabolomics approach to evaluate the influence of genetic and developmental factors on L. origanoides metabolism. We compared five adult plants and eight leaf developmental stages separately; the chemical analyses were performed via UHPLC-ESI-QTOF-MS/MS and the resulting data were processed in Progenesis QI 2.0 and in MetaboAnalyst 6.0 for statistical analysis. Luteolin-7-O-glucoside and kaempferol/luteolin were the most intense components in the negative and positive ion modes, respectively. A subtle chemical variation between individuals was found while the leaf development, conversely, strongly affected the chemical profile, which may ultimately result in variation in bioactivity. Altogether, we reported herein new perspectives on L. origanoides non-volatile components and the impact of intraspecific factors on this species' metabolism.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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