Concordance between homeostatic model assessment and triglyceride glucose index in assessing insulin resistance among HIV-infected patients.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Saudi Medical Journal Pub Date : 2025-02-01 DOI:10.15537/smj.2025.46.2.20240769

Gokcen Gurkok Budak, Aslı Vatan, Ertuğrul Güçlü, Oğuz Karabay

{"title":"Concordance between homeostatic model assessment and triglyceride glucose index in assessing insulin resistance among HIV-infected patients.","authors":"Gokcen Gurkok Budak, Aslı Vatan, Ertuğrul Güçlü, Oğuz Karabay","doi":"10.15537/smj.2025.46.2.20240769","DOIUrl":null,"url":null,"abstract":"Objectives: To evaluate the concordance between the triglyceride glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) in assessing insulin resistance (IR) in people living with HIV (PLWH). Additionally, we aimed to estimate a cut-off value for the TyG index in PLWH.Methods: This retrospective, observational study included medical records of patients diagnosed with HIV at Sakarya Training and Research Hospital from January 2019 to January 2024. Based on their HOMA-IR levels, PLWH patients were divided into 2 groups: Group A (patients without IR) and Group B (patients with IR).Results: In this study, insulin resistance was investigated in 147 people living with HIV (PLWH) between the ages of 18-68. Our results showed a significant positive linear relationship between HOMA-IR and the TyG index (r=0.628, p<0.001). We found the TyG Index cut-off value to predict IR in people living with HIV (PLWH) to be 8.25.Conclusion: Our study identified correlation between the TyG index and HOMA IR index in PLWH. The TyG index may serve as an effective alternative to HOMA-IR for evaluating insulin resistance in PLWH.\".","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 2","pages":"157-162"},"PeriodicalIF":1.5000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822928/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.15537/smj.2025.46.2.20240769","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: To evaluate the concordance between the triglyceride glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) in assessing insulin resistance (IR) in people living with HIV (PLWH). Additionally, we aimed to estimate a cut-off value for the TyG index in PLWH.

Methods: This retrospective, observational study included medical records of patients diagnosed with HIV at Sakarya Training and Research Hospital from January 2019 to January 2024. Based on their HOMA-IR levels, PLWH patients were divided into 2 groups: Group A (patients without IR) and Group B (patients with IR).

Results: In this study, insulin resistance was investigated in 147 people living with HIV (PLWH) between the ages of 18-68. Our results showed a significant positive linear relationship between HOMA-IR and the TyG index (r=0.628, p<0.001). We found the TyG Index cut-off value to predict IR in people living with HIV (PLWH) to be 8.25.

Conclusion: Our study identified correlation between the TyG index and HOMA IR index in PLWH. The TyG index may serve as an effective alternative to HOMA-IR for evaluating insulin resistance in PLWH.".

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

体内平衡模型评估与甘油三酯葡萄糖指数在评估hiv感染者胰岛素抵抗中的一致性

目的：评价甘油三酯葡萄糖（TyG）指数与胰岛素抵抗稳态模型评估（HOMA-IR）在评估HIV感染者（PLWH）胰岛素抵抗（IR）中的一致性。此外，我们旨在估计PLWH中TyG指数的临界值。方法：这项回顾性观察性研究包括2019年1月至2024年1月在Sakarya培训和研究医院诊断为HIV的患者的医疗记录。根据患者HOMA-IR水平将PLWH患者分为2组：A组（无IR患者）和B组（有IR患者）。结果：本研究调查了147例年龄在18-68岁之间的HIV感染者（PLWH）的胰岛素抵抗。我们的研究结果显示HOMA-IR与TyG指数呈显著的线性正相关（r=0.628, p）。结论：我们的研究确定了PLWH患者TyG指数与HOMA-IR指数之间存在相关性。TyG指数可作为评估PLWH胰岛素抵抗的有效替代HOMA-IR。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Saudi Medical Journal 医学-医学：内科

CiteScore

2.30

自引率

6.20%

发文量

203

审稿时长

12 months

期刊介绍： The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.