{"title":"Nanofibers-based dual enzyme mimics with pH-switchable catalytic function for H2O2 sensing and antibacterial application","authors":"Shumin Zhang, Fang Ding, Shaoda Huang, Xuehong Ren","doi":"10.1016/j.cej.2025.160602","DOIUrl":null,"url":null,"abstract":"Nanozymes with biosensing and antibacterial function bring new insights for infectious diseases diagnosis and therapy. Nevertheless, their pH associated enzyme-mimicking activity remains a significant restriction for multifunctional applications. Herein, we report a pH-responsive catalytic strategy with Cu doped carbonized bacterial cellulose (BC) nanofibers as dual-enzyme mimetics. The obtained nanofibers exhibited pH-switchable peroxidase (POD)-like and haloperoxidase (HPO)-like activities, which could catalyze the generation of hydroxyl radicals (<strong>∙</strong>OH) and oxidative Br (Br<sup>+</sup>) in the presence of H<sub>2</sub>O<sub>2</sub> for bacteria killing, as well as exhibited pH-responsive H<sub>2</sub>O<sub>2</sub> sensing ability with limits of detection (LOD) as low as 2.22 μM detected by colorimetric assay. The designed catalytic strategy provides a portable approach for nanozymes in disease monitoring and therapy.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"12 1","pages":""},"PeriodicalIF":13.3000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering Journal","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.cej.2025.160602","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Nanozymes with biosensing and antibacterial function bring new insights for infectious diseases diagnosis and therapy. Nevertheless, their pH associated enzyme-mimicking activity remains a significant restriction for multifunctional applications. Herein, we report a pH-responsive catalytic strategy with Cu doped carbonized bacterial cellulose (BC) nanofibers as dual-enzyme mimetics. The obtained nanofibers exhibited pH-switchable peroxidase (POD)-like and haloperoxidase (HPO)-like activities, which could catalyze the generation of hydroxyl radicals (∙OH) and oxidative Br (Br+) in the presence of H2O2 for bacteria killing, as well as exhibited pH-responsive H2O2 sensing ability with limits of detection (LOD) as low as 2.22 μM detected by colorimetric assay. The designed catalytic strategy provides a portable approach for nanozymes in disease monitoring and therapy.
期刊介绍：
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.
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