The long-term stability after regeneration therapy for tympanic membrane perforation

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY Auris Nasus Larynx Pub Date : 2025-02-13 DOI:10.1016/j.anl.2025.02.003

Masahiro Takahashi, Shin-ichiro Oka, Sakiko Furutate, Syogo Oyamada, Satoshi Iwasaki

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Abstract

Objective

To investigate the long-term stability of regenerative treatment for tympanic membrane perforation (TMP) using gelatin sponge, basic fibroblast growth factor (bFGF) and fibrin glue in a population with TMP closure.

Material and methods

Treatment could be performed up to four times until perforation closure was achieved. Cases in which perforation closure was finally achieved underwent 1 year of follow-up observation. Perforation closure rate was assessed more than 1 year after initial perforation closure, cases of reperforation were examined, and complications were considered.

Results

Postoperative observation after 1 year showed complete closure of the TM remained in 45 of the 54 cases (83.3 %). A high rate of perforation closure was thus maintained. Apart from five cases with small perforations, no complications such as dizziness, ear discharge, or cholesteatoma formation were observed.

Conclusion

These findings suggest the long-term stability of regeneration therapy using gelatin sponge, bFGF, and fibrin glue. This regeneration therapy appears feasible and safe, with a closure rate of TMP after this regeneration therapy equivalent to that of traditional tympanoplasty and myringoplasty.

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来源期刊

Auris Nasus Larynx 医学-耳鼻喉科学

CiteScore

3.40

自引率

5.90%

发文量

169

审稿时长

30 days

期刊介绍： The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science. Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed. Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.