Oral microbiota in colorectal cancer: Unraveling mechanisms and application potential

IF 5.1 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Life sciences Pub Date : 2025-02-11 DOI:10.1016/j.lfs.2025.123462

Xinran Zhang , Yixin Chen , Yuwei Xia , Shenghao Lin , Xinlei Zhou , Xi Pang , Jieru Yu , Leitao Sun

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Abstract

Colorectal cancer (CRC), with a rising prevalence, is the third most commonly diagnosed cancer and the third leading cause of cancer-related death. Studies have shown that a complex interplay between the development of CRC and alterations in the oral microbiome. Recent advancements in genomics and metagenomics have highlighted the significant roles of certain oral microbes, particularly Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum), in the progression of CRC. However, the detailed mechanisms by which the oral microbiota influence CRC development remain unclear. This review aims to elucidate the role of oral microbiota in CRC progression, evaluate their potential as biomarkers, and explore therapeutic strategies targeting these microbes. This review offers insights into the mechanisms underlying the interaction between oral microbiota and CRC, underscoring the potential of oral microbes as diagnostic and prognostic biomarkers, as well as therapeutic targets. Future research should focus on clarifying the exact pathways and developing innovative therapeutic strategies to enhance the diagnosis and treatment.

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结直肠癌的口腔微生物群：揭示机制和应用潜力

结直肠癌（CRC）的发病率不断上升，是第三大最常诊断的癌症，也是癌症相关死亡的第三大原因。研究表明，结直肠癌的发展与口腔微生物群的改变之间存在复杂的相互作用。基因组学和宏基因组学的最新进展强调了某些口腔微生物，特别是牙龈卟啉单胞菌（P. gingivalis）和核梭杆菌（F. nucleatum）在结直肠癌进展中的重要作用。然而，口腔微生物群影响结直肠癌发展的详细机制尚不清楚。本综述旨在阐明口腔微生物群在结直肠癌进展中的作用，评估其作为生物标志物的潜力，并探索针对这些微生物的治疗策略。这篇综述深入探讨了口腔微生物群与结直肠癌相互作用的机制，强调了口腔微生物作为诊断和预后生物标志物以及治疗靶点的潜力。未来的研究应集中在明确确切的途径和开发创新的治疗策略，以提高诊断和治疗。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.