A novel approach to non-surgical management of deep second-degree perianal burn in an immobile patient using platelet-rich plasma: A case report

Abstract

This case report presents a 24-year-old patient with severe mental and physical disabilities who sustained deep partial-thickness burns to the perianal and gluteal region. Conventional surgical interventions, such as skin grafting, were deemed unsuitable due to the high risk of infection and the patient’s non-compliance with specialized positioning. Instead, the innovative use of platelet-rich plasma (PRP) therapy was implemented, involving subdermal PRP injections and daily dressing changes. PRP, derived from the patient’s own blood, offers low immunogenicity and promotes wound healing by enhancing angiogenesis, modulating inflammation, and reducing oxidative stress. The patient showed significant wound healing and reepithelialization, avoiding the need for any surgery. This case highlights the efficacy of PRP in managing complex burn wounds and underscores the necessity for personalized treatment strategies, particularly for patients with significant comorbidities, where conventional methods may pose additional risks.