On the concordance between electrical source imaging, anatomical and functional neuroimaging in patients with focal epilepsy

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-04-01 Epub Date: 2025-01-31 DOI:10.1016/j.clinph.2024.12.021

Miguel Ley , Riccardo Zucca , Klaus Langohr , Panadés-de Oliveira Luisa , Alessandro Principe , Jaume Capellades , María Yolanda Aguilar , Rodrigo Rocamora

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Abstract

Objective

Limited knowledge exists regarding how electrical source imaging (ESI) of interictal epileptiform discharges (IEDs) aligns with findings from other neuroimaging modalities. This study investigates the relationships of interictal ESI with MRI, 18FDG PET, SISCOM, and voxel-based morphometry (VBM) during presurgical evaluation of drug-resistant epilepsy (DRE).

Methods

A cross-sectional study evaluated the concordance of IED locations from ESI using various inverse solutions (CLARA, LAURA, LORETA, SLORETA, SWLORETA, SSLOFO) with MRI lesions, 18FDG PET, SISCOM, and VBM grey matter abnormalities. The role of ESI in presurgical evaluation of DRE was assessed.

Results

Significant relationships were identified between the localization and distribution of IEDs identified by ESI and the various sets of neuroimages. SLORETA and SWLORETA exhibited the highest concordance and interlobar associations with MRI, 18FDG PET and SISCOM. The main cluster of IEDs proved helpful in locating the epileptogenic zone (EZ).

Conclusions

The distribution of IEDs identified by the ESI technique exhibited a high degree of significant relationships with other neuroimaging sources. Its use may prove valuable in defining the epileptogenic zone.

Significance

Combining ESI of IEDs with other neuroimaging techniques may be useful in the presurgical evaluation of DRE.

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局灶性癫痫患者的电源成像、解剖和功能神经成像的一致性研究

目的关于电源成像（ESI）如何与其他神经成像方式的结果相一致，目前的知识有限。本研究探讨了在术前评估耐药癫痫（DRE）时，间期ESI与MRI、18FDG PET、SISCOM和基于体素的形态学（VBM）的关系。方法横断面研究利用不同的逆解（CLARA、LAURA、LORETA、SLORETA、SWLORETA、SSLOFO）评估ESI中IED位置与MRI病变、18FDG PET、SISCOM和VBM灰质异常的一致性。评估ESI在术前评估DRE中的作用。结果ESI识别的ied的定位和分布与多组神经影像有显著关系。SLORETA和SWLORETA与MRI、18FDG PET和SISCOM表现出最高的一致性和叶间相关性。简易爆炸装置的主要集群被证明有助于定位癫痫区（EZ）。结论ESI技术鉴定的ied分布与其他神经影像学来源具有高度显著的相关性。它的使用在确定癫痫区方面可能被证明是有价值的。意义：将ied的ESI与其他神经影像学技术相结合，可能有助于术前评估DRE。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.