The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms

IF 2.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Biochemistry and Biophysics Pub Date : 2025-02-13 DOI:10.1007/s12013-025-01683-9

Farah Karam, Yara El Deghel, Rabah Iratni, Ali H. Dakroub, Ali H. Eid

{"title":"The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms","authors":"Farah Karam, Yara El Deghel, Rabah Iratni, Ali H. Dakroub, Ali H. Eid","doi":"10.1007/s12013-025-01683-9","DOIUrl":null,"url":null,"abstract":"<div><p>Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. CRC can manifest as inherited syndromes (10%), familial clustering (20%), or sporadic forms (70%). The gut microbiota, comprising mainly firmicutes and bacteroidetes, play a key role in CRC development and prevention. Indeed, CRC progression is influenced by the dynamic interaction between the gut microbiota, the intestinal barrier, the immune system, and the production of short-chain fatty acids. Not surprisingly, imbalance in the gut microbiota, termed dysbiosis, has been linked to CRC due to ensuing chronic inflammation, DNA damage, and oxidative stress. This may explain the notion that probiotics and fecal microbiota transplantation offer potential strategies for CRC prevention and treatment by restoring microbial balance and enhancing anti-cancer immune responses. This review appraises the roles of gut microbiota in promoting or preventing CRC. It also discusses the mechanistic interplay between microbiota composition, the intestinal barrier, and the immune system, with the hope of developing potential therapeutic strategies.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":"83 3","pages":"2637 - 2650"},"PeriodicalIF":2.5000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12013-025-01683-9.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biochemistry and Biophysics","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s12013-025-01683-9","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. CRC can manifest as inherited syndromes (10%), familial clustering (20%), or sporadic forms (70%). The gut microbiota, comprising mainly firmicutes and bacteroidetes, play a key role in CRC development and prevention. Indeed, CRC progression is influenced by the dynamic interaction between the gut microbiota, the intestinal barrier, the immune system, and the production of short-chain fatty acids. Not surprisingly, imbalance in the gut microbiota, termed dysbiosis, has been linked to CRC due to ensuing chronic inflammation, DNA damage, and oxidative stress. This may explain the notion that probiotics and fecal microbiota transplantation offer potential strategies for CRC prevention and treatment by restoring microbial balance and enhancing anti-cancer immune responses. This review appraises the roles of gut microbiota in promoting or preventing CRC. It also discusses the mechanistic interplay between microbiota composition, the intestinal barrier, and the immune system, with the hope of developing potential therapeutic strategies.

Graphical Abstract

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

肠道微生物群与结直肠癌：潜在机制的综合综述。

结直肠癌（CRC）是全球癌症相关死亡的第二大原因。虽然由于更好的筛查，结直肠癌的发病率和死亡率总体上有所下降，但50岁以下成年人的发病率却有所上升。CRC可表现为遗传综合征（10%）、家族聚集性（20%）或散发形式（70%）。肠道菌群，主要包括厚壁菌门和拟杆菌门，在结直肠癌的发展和预防中起关键作用。事实上，结直肠癌的进展受到肠道微生物群、肠道屏障、免疫系统和短链脂肪酸产生之间的动态相互作用的影响。不足为奇的是，由于随后的慢性炎症、DNA损伤和氧化应激，被称为生态失调的肠道微生物群失衡与结直肠癌有关。这可能解释了益生菌和粪便微生物群移植通过恢复微生物平衡和增强抗癌免疫反应为CRC预防和治疗提供潜在策略的概念。本文综述了肠道菌群在促进或预防结直肠癌中的作用。它还讨论了微生物群组成，肠道屏障和免疫系统之间的机制相互作用，希望开发潜在的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.