Canine Multicentric Lymphoma: Diagnostic, Treatment, and Prognostic Insights.

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animals Pub Date : 2025-01-30 DOI:10.3390/ani15030391

Michelle do Carmo Pereira Rocha, Diana Araújo, Fátima Carvalho, Nuno Vale, Josiane Morais Pazzini, Marcus Antônio Rossi Feliciano, Andrigo Barboza De Nardi, Irina Amorim

引用次数: 0

Abstract

Lymphoma accounts for 24% of all documented canine neoplasms and 85% of hematological malignancies, while multicentric lymphoma corresponds to 84% of all canine lymphomas. Canine lymphomas of B-cell origin account for 60% to 80% of lymphomas. Similar to humans, the histologic grade, architecture, as well as immunophenotype determination, are crucial. These lesions are the most prevalent spontaneous tumors in dogs and this species may be a valuable animal model for the study of human non-Hodgkin's lymphoma. Therefore, it is important to investigate and assess therapeutic responses and to seek predictive and prognostic factors in order to allow for the development of an individualized and more effective therapy that increases survival. This review aims to describe current knowledge on the diagnosis, treatment, and prognostic factors of canine multicentric lymphoma.

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犬多中心淋巴瘤：诊断、治疗和预后洞察。

淋巴瘤占所有犬肿瘤的24%，占血液系统恶性肿瘤的85%，而多中心淋巴瘤占所有犬淋巴瘤的84%。犬b细胞源性淋巴瘤占淋巴瘤的60% ~ 80%。与人类相似，组织学分级、结构以及免疫表型测定是至关重要的。这些病变是犬中最常见的自发肿瘤，该物种可能是研究人类非霍奇金淋巴瘤的有价值的动物模型。因此，重要的是调查和评估治疗反应，并寻求预测和预后因素，以便制定个性化和更有效的治疗方法，提高生存率。本文综述了犬多中心淋巴瘤的诊断、治疗和预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).