Unlocking Gut Health: The Potent Role of Stilbenoids in Intestinal Homeostasis.

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animals Pub Date : 2025-02-03 DOI:10.3390/ani15030417

Tiantian Meng, Ziwei Wen, Xiaofang Cheng, Cencen Li, Pengpeng Zhang, Dingfu Xiao, Yongjie Xu

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Abstract

Stilbenoids are a class of naturally occurring phenolic compounds found in various plant species, characterized by a stilbene backbone with diverse substituents that confer a range of biological activities. These compounds exhibit antioxidant, anti-inflammatory, and antimicrobial properties, making them promising candidates for improving intestinal health. The intestinal tract plays a critical role in nutrient digestion, absorption, and immune defense, and maintaining its integrity is vital for animal growth. Stilbenoids contribute to gut health by enhancing intestinal morphology, supporting mucosal immune responses, regulating gut microbiota composition, modulating metabolic pathways, and maintaining mitochondrial health. This review provides a comprehensive analysis of key stilbenoids, including resveratrol, pterostilbene, piceatannol, and oxyresveratrol, focusing on their biological effects and regulatory mechanisms. By highlighting their roles in mitigating intestinal inflammation and promoting gut function, this review provides a basis for the practical application of stilbenoids in animal health and husbandry.

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解锁肠道健康：芪类化合物在肠道内稳态中的有效作用。

二苯乙烯类化合物是一类天然存在的酚类化合物，存在于各种植物物种中，其特点是二苯乙烯骨架具有多种取代基，具有一系列生物活性。这些化合物具有抗氧化、抗炎和抗菌的特性，使它们成为改善肠道健康的有希望的候选者。肠道在营养物质的消化、吸收和免疫防御中起着至关重要的作用，保持肠道的完整性对动物的生长至关重要。苯乙烯类化合物通过改善肠道形态、支持粘膜免疫反应、调节肠道微生物群组成、调节代谢途径和维持线粒体健康来促进肠道健康。本文综述了白藜芦醇、紫檀芪、皮杉醇、氧化白藜芦醇等主要甾类化合物的生物学作用及其调控机制。本文通过对其在减轻肠道炎症和促进肠道功能方面的作用进行综述，为其在动物保健和畜牧业中的实际应用提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).