The antioxidant role of aromatic plant extracts in managing neurodegenerative diseases: A comprehensive review

IF 3.7 3区医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI:10.1016/j.brainresbull.2025.111253

Youyang Zhu , Miao Tian , Shiyu Lu , Yuliang Qin , Ting Zhao , Hongling Shi , Zhaofu Li , Dongdong Qin

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Abstract

Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS), and others. They are caused by lesions in cells and tissues of the central nervous system, resulting in corresponding dysfunctions and consequent decline in cognitive and motor functions. Neural tissues are extremely vulnerable to oxidative stress, which plays critical biological roles in NDDs. Aromatic compounds are found extensively in natural plants and have substantial effects of anti-oxidative stress damage, which not only have a wide range of research applications in cosmetics, foods, etc., but are also frequently utilized in the treatment of various central nervous system diseases. This review summarizes the relevant oxidative stress mechanisms in NDDs (AD, PD, HD, and ALS) and reviews aromatic compounds such as polyphenols, terpenoids, and flavonoids that can be used in the management of neurodegenerative diseases, as well as their specific mechanisms of antioxidant action. This review will serve as a reference for future experimental studies on neurodegenerative illnesses while also offering fresh insights into clinical therapy.

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芳香植物提取物在神经退行性疾病治疗中的抗氧化作用综述

神经退行性疾病（ndd）是一类认知和运动障碍，包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）、肌萎缩侧索硬化症（ALS）等。它们是由中枢神经系统的细胞和组织受损引起的，导致相应的功能障碍，从而导致认知和运动功能下降。神经组织极易受到氧化应激的影响，氧化应激在ndd中起着重要的生物学作用。芳香族化合物广泛存在于天然植物中，具有显著的抗氧化应激损伤作用，不仅在化妆品、食品等方面有着广泛的研究应用，而且经常被用于治疗各种中枢神经系统疾病。本文综述了ndd （AD、PD、HD和ALS）的氧化应激机制，综述了可用于神经退行性疾病治疗的芳香族化合物如多酚、萜类和黄酮类化合物及其抗氧化作用的具体机制。本文综述将为今后神经退行性疾病的实验研究提供参考，同时也为临床治疗提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.