Association between parental high-sensitive C-reactive protein and hypertension in offspring: an intergenerational study.

IF 3.6 Q2 PERIPHERAL VASCULAR DISEASE Clinical Hypertension Pub Date : 2025-02-01 eCollection Date: 2025-01-01 DOI:10.5646/ch.2025.31.e6

Xuemei Yang, Feipeng Cui, Shuohua Chen, Guodong Wang, Shouling Wu, Liufu Cui

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Abstract

Background: Although the association between C-reactive protein (CRP) and hypertension has been acknowledged, the associations between parental high-sensitive CRP (hs-CRP) levels and offspring hypertension remain unexplored. To investigate the relationship between parental and offspring hs-CRP levels, as well as the association between parental hs-CRP levels and offspring hypertension.

Methods: We included 6,848 father-offspring and 1,588 mother-offspring pairs from the Kailuan study. Time-weighted average hs-CRP (TWA-CRP) was calculated by cumulative hs-CRP/Time_start-end. Hypertension were defined as systolic blood pressure (BP) ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg. The generalized estimating equation model was used to explored the relationship between parental TWA-CRP and offspring TWA-CRP, and the association between parental TWA-CRP and offspring hypertension. The Cox proportional hazard model was applied to examine the relationship between offspring TWA-CRP and hypertension risk.

Results: The regression coefficient and 95% confidence intervals (CIs) for offspring TWA-CRP were 0.50 (0.38-0.62) in father-offspring pairs and 0.53 (0.29-0.76) in mother-offspring pairs with high parental TWA-CRP. The odds ratios (ORs) and 95% CIs for offspring hypertension were 1.30 (1.11-1.52) in father-offspring pairs and 1.32 (0.95-1.84) in mother-offspring pairs with high parental TWA-CRP. When both parent and offspring had a high TWA-CRP, the ORs (95% CIs) for offspring hypertension were 1.92 (1.43-2.56) in father-offspring pairs and 2.44 (1.35-4.35) in mother-offspring pairs. The hazard ratios and 95% CIs for offspring hypertension were 1.43 (1.15-1.76) in father-offspring pairs and 2.48 (1.18-5.22) in mother-offspring pairs with high offspring TWA-CRP.

Conclusions: Parental high TWA-CRP may increase the risk of offspring hypertension.

Trial registration: Chinese Clinical Trial Registry Identifier: ChiCTR2000029767.

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亲代高敏感c反应蛋白与后代高血压的关系：一项代际研究。

背景：虽然c反应蛋白（CRP）与高血压之间的关系已得到承认，但亲代高敏CRP （hs-CRP）水平与后代高血压之间的关系仍未被探索。探讨亲代与子代hs-CRP水平的关系，以及亲代hs-CRP水平与子代高血压的关系。方法：我们纳入了来自开滦研究的6848对父系后代和1588对母系后代。时间加权平均hs-CRP （TWA-CRP）计算方法为累积hs-CRP/Timestart-end。高血压定义为收缩压(BP)≥140 mmHg和/或舒张压≥90 mmHg。采用广义估计方程模型探讨亲代TWA-CRP与子代TWA-CRP的关系，以及亲代TWA-CRP与子代高血压的关系。采用Cox比例风险模型检验后代TWA-CRP与高血压风险的关系。结果：父子对后代TWA-CRP的回归系数为0.50(0.38 ~ 0.62)，高亲本TWA-CRP的母子对后代TWA-CRP的95%置信区间为0.53（0.29 ~ 0.76）。父系后代高血压的比值比（ORs）和95% ci分别为1.30（1.11-1.52）和1.32（0.95-1.84）。当父母和后代都有高TWA-CRP时，父子对后代高血压的ORs （95% CIs）为1.92(1.43 ~ 2.56)，母子对为2.44（1.35 ~ 4.35）。高TWA-CRP的父系后代高血压的危险比和95% ci分别为1.43（1.15-1.76）和2.48（1.18-5.22）。结论：父母高TWA-CRP可能增加后代高血压的风险。试验注册：中国临床试验注册号：ChiCTR2000029767。

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