Hepatoprotective Effect of a Kalanchoe pinnata-Based Beverage Against Carbon Tetrachloride- and Gentamicin-Induced Hepatotoxicity in Wistar Rats.

IF 6.8 4区医学 Q1 NUTRITION & DIETETICS Journal of the American Nutrition Association Pub Date : 2025-02-12 DOI:10.1080/27697061.2024.2442615

Kanza Saeed, Muhammad Farhan Jahangir Chughtai, Samreen Ahsan, Tariq Mehmood, Muhammad Zubair Khalid, Adnan Khaliq, Muhammad Zuhair, Waseem Khalid, Tawfiq Alsulami, Douglas Law, Emery Lenge Mukonzo

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Abstract

Objective: Chronic liver diseases are accountable for approximately 2 million deaths annually. The current study aimed to test the putative prophylactic role of Kalanchoe pinnata against hepatic stress.

Method: Kalanchoe pinnata leaf extracts utilized in beverage production were obtained via 3 different extraction techniques (conventional solvent extraction, supercritical fluid extraction, microwave-assisted extraction).

Results: The highest values on 2,2-diphenyl-1-picrylhydrazyl, ferric reducing antioxidant power, and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid assay were from a beverage prepared with supercritical fluid extract. When the prophylactic aspects of a Kalanchoe pinnata-based beverage were explored against carbon tetrachloride- (CCl₄-) and gentamicin-induced hepatotoxic conditions in male Wistar rats, results revealed a reduction in serum aspartate aminotransferase, serum alkaline phosphatase, serum alanine transaminase, and bilirubin levels in rats with CCl₄ and gentamicin-induced toxicity. The study also concluded that the administration of a therapeutic beverage significantly improved serum total protein, albumin, and globulin levels in Kalanchoe pinnata-treated rats.

Conclusions: Our findings support the ameliorative potential of Kalanchoe pinnata against liver diseases.

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