Molecular structural arrangement in quorum sensing and bacterial metabolic production.

IF 4.2 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY World journal of microbiology & biotechnology Pub Date : 2025-02-13 DOI:10.1007/s11274-025-04280-3

Victor U Chigozie, Morteza Saki, Charles O Esimone

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Abstract

Quorum sensing (QS) regulates bacterial behaviors such as biofilm formation, virulence, and metabolite production through signaling molecules like acyl-homoserine lactones (AHLs), peptides, and AI-2. These signals are pivotal in bacterial communication, influencing pathogenicity and industrial applications. This review explores the molecular architecture of QS signals and their role in metabolite production, emphasizing structural modifications that disrupt bacterial communication to control virulence and enhance industrial processes. Key findings highlight the development of synthetic QS analogs, engineered inhibitors, and microbial consortia as innovative tools in biotechnology and medicine. The review underscores the potential of molecular engineering in managing microbial behaviors and optimizing applications like biofuel production, bioplastics, and anti-virulence therapies. Additionally, cross-species signaling mechanisms, particularly involving AI-2, reveal new opportunities for regulating interspecies cooperation and competition. This synthesis aims to bridge molecular insights with practical applications, showcasing how QS-based technologies can drive advancements in microbial biotechnology and therapeutic strategies.

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群体感应与细菌代谢产物的分子结构排列。

群体感应（QS）通过酰基同丝氨酸内酯（AHLs）、肽和AI-2等信号分子调节细菌的行为，如生物膜的形成、毒力和代谢物的产生。这些信号是细菌交流的关键，影响致病性和工业应用。这篇综述探讨了QS信号的分子结构及其在代谢物生产中的作用，强调了结构修饰破坏细菌通讯以控制毒力和加强工业过程。主要发现突出了合成QS类似物、工程抑制剂和微生物联合体作为生物技术和医学创新工具的发展。这篇综述强调了分子工程在管理微生物行为和优化生物燃料生产、生物塑料和抗毒治疗等应用方面的潜力。此外，跨物种信号机制，特别是涉及AI-2，揭示了调节物种间合作和竞争的新机会。该合成旨在将分子见解与实际应用相结合，展示基于量子问题的技术如何推动微生物生物技术和治疗策略的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of microbiology & biotechnology 工程技术-生物工程与应用微生物

CiteScore

6.30

自引率

2.40%

发文量

257

审稿时长

2.5 months

期刊介绍： World Journal of Microbiology and Biotechnology publishes research papers and review articles on all aspects of Microbiology and Microbial Biotechnology. Since its foundation, the Journal has provided a forum for research work directed toward finding microbiological and biotechnological solutions to global problems. As many of these problems, including crop productivity, public health and waste management, have major impacts in the developing world, the Journal especially reports on advances for and from developing regions. Some topics are not within the scope of the Journal. Please do not submit your manuscript if it falls into one of the following categories: · Virology · Simple isolation of microbes from local sources · Simple descriptions of an environment or reports on a procedure · Veterinary, agricultural and clinical topics in which the main focus is not on a microorganism · Data reporting on host response to microbes · Optimization of a procedure · Description of the biological effects of not fully identified compounds or undefined extracts of natural origin · Data on not fully purified enzymes or procedures in which they are applied All articles published in the Journal are independently refereed.