Inhibitory activity of 2-benzimidazolylurea on gastric acid secretion in rats

S. Trivulzio
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引用次数: 0

Abstract

2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects.

The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole.

The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pylocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine.

BIU probably depresses gastric acid secretion by interferring with both histamine and acetylcholine receptors.

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2-苯并咪唑脲对大鼠胃酸分泌的抑制作用
2-苯并咪唑脲(BIU)减少胃酸分泌。抗隐活性似乎与抗组胺和抗毒作用有关。BIU的抗组胺活性主要表现在其对倍唑刺激下的胃酸分泌的抑制作用和对离体豚鼠耳廓的抑制作用。BIU的抗毒蕈碱活性出现在几个实验中:该分子能降低大鼠受碳巴酚刺激的胃酸分泌,抑制麻醉猫受新斯的明刺激的十二指肠运动,减轻幽门卡平引起的离体豚鼠气管张力增高,还能抑制乙酰胆碱刺激的豚鼠回肠活性。BIU可能通过干扰组胺和乙酰胆碱受体抑制胃酸分泌。
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