The 137Cs contents was determined in 406 plant drug samples harvested in 1986 and 1987 after the Chernobyl accident and in their preparations. Very high values were found in drugs produced in Eastern Europe and in Italy. The decoction contain about 80% of 137Cs present in the drugs.
Smilax macrophylla Vers., administred per os at the doses of 1 or 2 g/kg in normal rats or in rats made hyperuricemic and hyperuricosuric by potassium oxonate (250 mg/Kg p.o.) or fructose (4 g/Kg p.o.) does not modify diuresis, but increases the excretion of uric acid and allantoin in normal rats and in those pretreated with fructose, whereas it is inactive in oxonate pretreated rats. Allantoinemia is not modified by fructose or oxonate, whereas uricemia is modified.
From the alcoholic extract of fresh rhizomes from Magydaris Pastinacea the glycosidic fraction was separated: it appears to be made up of seven different constituents one of which, 7-0-β-glucopyranosil-8(2′,3′-dihydroxy-3′methyl)-butylcoumarin isolated and identified by us, is relatively more abundant.
An anaphylactic reaction was induced with the specific antigen (1 mg Ovalbumin) in perfused lungs from actively sensitized guinea-pigs in order to evaluate the ability of the ginkgolide BN-52021 (0.4, 4, 40 ug/ml) to modulate the mediator release. The ginkgolide reduces in a dose dependent manner the release of histamine (22%, 45% and 75% of inhibition), TXB2 (77% of inhibition at the maximal dose used) and of SRS-A to a lower extent (only 33% at the higher dose). BN-52021 was still powerful in reducing histamine release induced by immunological reaction in indomethacin treated animals. In conclusion, the present “in-vitro” results confirm the beneficial activity of this ginkgolide, already demonstrated by the same Authors in “in-vivo” experiment, in anaphylactic reactions, and further substantiate the wider spectrum of action of the ginkgolide beside its specific PAF receptor antagonistic activity.
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