UK cancer vaccine advance - Recognising and realising opportunities.

Cambridge prisms, Precision medicine Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI:10.1017/pcm.2024.5
Charles Craddock, Philip Earwaker, Matthew Fittall, Elisa Fontana, Divya Ganesh, Marco Gerlinger, Qamar Ghafoor, Robert P Jones, Victoria Kunene, Lennard Lee, Rebecca Lee, Siow-Ming Lee, Mark Linch, Martin Little, Justin Liu, Hayley McKenzie, Russell Petty, David J Pinato, Thomas Powles, Andrew Protheroe, Tim Robinson, Paul J Ross, Kai Keen Shiu, James Spicer, Stefan Symeonides, Michael Tilby, Dale Vimalachandran, Jenny Y Wang, Andrew Wardley, Helen Winter
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Abstract

Vaccines have revolutionised the field of medicine, eradicating and controlling many diseases. Recent pandemic vaccine successes have highlighted the accelerated pace of vaccine development and deployment. Leveraging this momentum, attention has shifted to cancer vaccines and personalised cancer vaccines, aimed at targeting individual tumour-specific abnormalities. The UK, now regarded for its vaccine capabilities, is an ideal nation for pioneering cancer vaccine trials. This article convened experts to share insights and approaches to navigate the challenges of cancer vaccine development with personalised or precision cancer vaccines, as well as fixed vaccines. Emphasising partnership and proactive strategies, this article outlines the ambition to harness national and local system capabilities in the UK; to work in collaboration with potential pharmaceutic partners; and to seize the opportunity to deliver the pace for rapid advances in cancer vaccine technology.

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英国癌症疫苗进展-认识和实现机会。
疫苗彻底改变了医学领域,根除和控制了许多疾病。最近在大流行性流感疫苗方面取得的成功突出表明,疫苗开发和部署的步伐正在加快。利用这一势头,注意力已转向癌症疫苗和个性化癌症疫苗,旨在针对个别肿瘤特异性异常。英国现在以其疫苗能力而闻名,是开展癌症疫苗试验的理想国家。这篇文章召集了专家,分享了个性化或精确癌症疫苗以及固定疫苗开发癌症疫苗挑战的见解和方法。本文强调伙伴关系和积极主动的战略,概述了在英国利用国家和地方系统能力的雄心;与潜在的医药合作伙伴合作;并抓住机会加快癌症疫苗技术的快速发展。
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