Differences in anti-obesity effects between raw and ripened Pu-erh tea polyphenols: impact on gut microbiota enterotypes

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of the Science of Food and Agriculture Pub Date : 2025-02-13 DOI:10.1002/jsfa.14157

Zichen Ning, Weipeng Pan, Yayan Huang, Na Zhang, Bingde Zheng, Xueqin Zhang, Meitian Xiao, Yucheng Yang, Jing Ye

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Abstract

Background

Pu-erh tea, a dark tea from China, is classified into raw and ripened types. Both have significant anti-obesity effects. Polyphenols are among their major bioactive components. This study aimed to explore the anti-obesity properties and mechanisms of raw (R-TP) and ripened (F-TP) Pu-erh tea polyphenols.

Results

The results showed that R-TP and F-TP significantly reduced body weight, improved insulin resistance, and enhanced glucose and lipid metabolism in high-fat-diet (HFD)-induced obese mice. Mild differences were observed in their impact on fat metabolism, carbohydrate metabolism, and inflammation levels. Both R-TP and F-TP were able to restore the disrupted intestinal flora caused by HFD treatment, returning them to a composition and levels similar to those of normal mice. Interestingly, the gut microbiota of all the mice could be reclassified into three enterotypes (enterotype Type-1, Type-2, and Type-HFD). Lactobacillaceae predominated in Type-1. Lactobacillaceae, Muribaculaceae, and Lachnospiraceae were the most common in Type-2. Type-HFD was primarily composed of Atopobiaceae, Lachnospiraceae, Lactobacillaceae, Ruminococcaceae, and Erysipelotrichaceae. The small differences in the effects of R-TP and F-TP may be due to variations in enterotypes.

Conclusion

These findings indicate that R-TP and F-TP can alleviate obesity by regulating the enterotype of gut microbiota, suggesting that they possess the potential for application in the treatment of obesity and the development of anti-obesity agents. © 2025 Society of Chemical Industry.

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生的和熟的普洱茶多酚抗肥胖作用的差异：对肠道微生物群肠型的影响

背景：普洱茶是一种来自中国的黑茶，分为生的和熟的两种。两者都有显著的抗肥胖作用。多酚是其主要的生物活性成分之一。本研究旨在探讨生（R-TP）和熟（F-TP）普洱茶多酚的抗肥胖特性及其机制。结果：结果表明，R-TP和F-TP可显著降低高脂饮食（HFD）诱导的肥胖小鼠的体重，改善胰岛素抵抗，增强糖脂代谢。它们对脂肪代谢、碳水化合物代谢和炎症水平的影响略有不同。R-TP和F-TP都能恢复HFD治疗引起的肠道菌群紊乱，使其恢复到与正常小鼠相似的组成和水平。有趣的是，所有小鼠的肠道微生物群都可以重新分类为三种肠型（肠型Type-1， Type-2和Type-HFD）。乳酸菌科在1型中占优势。2型细菌中以乳酸菌科、乳酸菌科和毛缕菌科最常见。hfd型主要由atopobibiaceae、Lachnospiraceae、Lactobacillaceae、Ruminococcaceae和丹毒杆菌科组成。R-TP和F-TP作用的微小差异可能是由于肠型的差异。结论：R-TP和F-TP可通过调节肠道菌群的肠型来减轻肥胖，在肥胖治疗和抗肥胖药物的开发中具有应用潜力。©2025化学工业协会。

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.