A Prediction Nomogram for Long-Term Facial Nerve Function Following Large Vestibular Schwannoma Resection.

Abstract

Objective: The purpose of this study was to generate a nomogram for predicting long-term facial nerve (FN) function at 3 months following large vestibular schwannoma (VS) resection.

Materials and methods: Retrospective data were evaluated from patients who underwent VS resection from May 2014 to May 2023 at Huashan Hospital. The nomogram was conducted based on the results of univariate and multivariate logistic regression analysis of the risk factors for poor long-term FN function after VS resection.

Results: A total of 166 cases were finally included in this study. The univariate and multivariate logistic regression analysis showed that tumor size [P=0.022, odds ratio (OR): 1.11, 95% CI: 1.02-1.22), intraoperative stimulation threshold (ST) (P=0.005, OR: 12.17, 95% CI: 2.10-70.68), tumor type (P=0.009, OR: 7.46, 95% CI: 1.64-33.86) and 3-month postoperative HB grade (P=0.005, OR: 0.883, 95% CI: 0.062-12.61) were independent risk factors for poor long-term FN function. A nomogram was conducted based on these indicators, which demonstrated good discrimination and favorable calibration.

Conclusion: A nomogram based on 4 indicators was conducted to predict long-term FN function at 3 months following large VS resection. Patients presented with little chance of long-term FN recovery are candidates for early intervention.