The flowers extracts of Citrus aurantium regulates fat metabolism in obese C57BL/6J mice by improving intestinal microbiota disorders.

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of the Science of Food and Agriculture Pub Date : 2025-02-13 DOI:10.1002/jsfa.14139

Ke-Xin Hao, Chun-Yan Shen, Jian-Guo Jiang

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引用次数: 0

Abstract

Background: Obesity can lead to many diseases such as diabetes, hypertension, cancer and cardiovascular diseases, which seriously affect people's quality of life and health.

Aims of the study: To investigate the main components and potential of n-butanol extract from Citrus aurantium L. var. amara Engl to reduce lipid accumulation and to explore its modulatory effects on the gut microbiota.

Methods: The main components of n-butanol extract were analyzed using liquid chromatography quadrupole trap mass spectrometry (LC-QTRAP-MS) and a high-fat diet-induced obese mouse model was established to analyze its effects on the determination of gene expression levels and intestinal microbiota using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and 16S rRNA gene sequence method.

Results: The n-butanol extract mainly consists of 15 components, and it could significantly inhibit weight gain, reduce liver coefficient and improve oxidative damage. By regulating the expression of related genes, it inhibited hepatic steatosis and hypertrophy of epididymal tissue. The n-butanol extract increased the diversity of intestinal microbiota, improved the composition and structure of the flora, and reversed the high-fat diet-induced disturbance of intestinal microbiota in mice.

Conclusion: These results indicated that the n-butanol extract of C. aurantium could inhibit lipid accumulation and provide a more comprehensive basis for the development and utilization of C. aurantium in anti-obesity activity. © 2025 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.